Journal article
A new technique with high reproducibility to estimate renal oxygenation using BOLD-MRI in chronic kidney disease.
- Piskunowicz M Department of Nephrology and Hypertension, CHUV, Lausanne, Switzerland; Department of Radiology, Medical University of Gdansk, Gdansk, Poland.
- Hofmann L Department of Nephrology and Hypertension, Bern University Hospital, Bern, Switzerland.
- Zuercher E Department of Nephrology and Hypertension, CHUV, Lausanne, Switzerland.
- Bassi I Department of Nephrology and Hypertension, CHUV, Lausanne, Switzerland.
- Milani B Department of Nephrology and Hypertension, CHUV, Lausanne, Switzerland.
- Stuber M Department of Radiology, CHUV, Lausanne, Switzerland.
- Narkiewicz K Department of Hypertension and Diabetology, Medical University of Gdansk, Poland.
- Vogt B Department of Nephrology and Hypertension, CHUV, Lausanne, Switzerland; Department of Nephrology and Hypertension, Bern University Hospital, Bern, Switzerland.
- Burnier M Department of Nephrology and Hypertension, CHUV, Lausanne, Switzerland.
- Pruijm M Department of Nephrology and Hypertension, CHUV, Lausanne, Switzerland. Electronic address: mennopruijm@hotmail.com.
- 2014-12-20
Published in:
- Magnetic resonance imaging. - 2015
BOLD-MRI
Chronic kidney disease
Concentric objects
Furosemide
Imaging analysis
Onion peel technique
Region of interest
Reproducibility
Aged
Automation
Electronic Data Processing
Female
Furosemide
Glomerular Filtration Rate
Healthy Volunteers
Humans
Image Processing, Computer-Assisted
Kidney
Kidney Cortex
Magnetic Resonance Imaging
Male
Middle Aged
Observer Variation
Oxygen Consumption
Prognosis
Renal Insufficiency, Chronic
Reproducibility of Results
Software
English
OBJECTIVES
To assess inter-observer variability of renal blood oxygenation level-dependent MRI (BOLD-MRI) using a new method of analysis, called the concentric objects (CO) technique, in comparison with the classical ROI (region of interest)-based technique.
METHODS
MR imaging (3T) was performed before and after furosemide in 10 chronic kidney disease (CKD) patients (mean eGFR 43±24ml/min/1.73m(2)) and 10 healthy volunteers (eGFR 101±28ml/min1.73m(2)), and R2* maps were determined on four coronal slices. In the CO-technique, R2* values were based on a semi-automatic procedure that divided each kidney in six equal layers, whereas in the ROI-technique, all circles (ROIs) were placed manually in the cortex and medulla. The mean R2*values as assessed by two independent investigators were compared.
RESULTS
With the CO-technique, inter-observer variability was 0.7%-1.9% across all layers in non-CKD, versus 1.6%-3.8% in CKD. With the ROI-technique, median variability for cortical and medullary R2* values was 3.6 and 6.8% in non-CKD, versus 4.7 and 12.5% in CKD; similar results were observed after furosemide.
CONCLUSION
The CO-technique offers a new, investigator-independent, highly reproducible alternative to the ROI-based technique to estimate renal tissue oxygenation in CKD.
To assess inter-observer variability of renal blood oxygenation level-dependent MRI (BOLD-MRI) using a new method of analysis, called the concentric objects (CO) technique, in comparison with the classical ROI (region of interest)-based technique.
METHODS
MR imaging (3T) was performed before and after furosemide in 10 chronic kidney disease (CKD) patients (mean eGFR 43±24ml/min/1.73m(2)) and 10 healthy volunteers (eGFR 101±28ml/min1.73m(2)), and R2* maps were determined on four coronal slices. In the CO-technique, R2* values were based on a semi-automatic procedure that divided each kidney in six equal layers, whereas in the ROI-technique, all circles (ROIs) were placed manually in the cortex and medulla. The mean R2*values as assessed by two independent investigators were compared.
RESULTS
With the CO-technique, inter-observer variability was 0.7%-1.9% across all layers in non-CKD, versus 1.6%-3.8% in CKD. With the ROI-technique, median variability for cortical and medullary R2* values was 3.6 and 6.8% in non-CKD, versus 4.7 and 12.5% in CKD; similar results were observed after furosemide.
CONCLUSION
The CO-technique offers a new, investigator-independent, highly reproducible alternative to the ROI-based technique to estimate renal tissue oxygenation in CKD.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.mri.2014.12.002
- PMID 25523609
- Persistent URL
- https://sonar.ch/global/documents/57825
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