Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease.

Zufferey V; Donati A; Popp J; Meuli R; Rossier J; Frackowiak R; Draganski B; von Gunten A; Kherif F

doi:10.1016/j.dadm.2017.05.002

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Journal article

Neuroticism, depression, and anxiety traits exacerbate the state of cognitive impairment and hippocampal vulnerability to Alzheimer's disease.

Zufferey V Laboratoire de Recherche en Neuroimagerie (LREN), Département des neurosciences cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Lausanne, Switzerland.
Donati A Service of Old Age Psychiatry, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly-Lausanne, Switzerland.
Popp J Service of Old Age Psychiatry, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly-Lausanne, Switzerland.
Meuli R Department of Diagnostic and Interventional Radiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Rossier J Faculty of Social and Political Sciences, Institute of Psychology, University of Lausanne, Lausanne, Switzerland.
Frackowiak R Laboratoire de Recherche en Neuroimagerie (LREN), Département des neurosciences cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Lausanne, Switzerland.
Draganski B Laboratoire de Recherche en Neuroimagerie (LREN), Département des neurosciences cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Lausanne, Switzerland.
von Gunten A Service of Old Age Psychiatry, Department of Psychiatry, Centre Hospitalier Universitaire Vaudois, Prilly-Lausanne, Switzerland.
Kherif F Laboratoire de Recherche en Neuroimagerie (LREN), Département des neurosciences cliniques, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Lausanne, Switzerland.

2017-06-28

Published in:

Alzheimer's & dementia (Amsterdam, Netherlands). - 2017

English INTRODUCTION
Certain personality traits are associated with higher risk of Alzheimer's disease, similar to cognitive impairment. The identification of biological markers associated with personality in mild cognitive impairment could advance the early detection of Alzheimer's disease.

METHODS
We used hierarchical multivariate linear models to quantify the interaction between personality traits, state of cognitive impairment, and MRI biomarkers (gray matter brain volume, gray matter mean water diffusion) in the medial temporal lobe (MTL).

RESULTS
Over and above a main effect of cognitive state, the multivariate linear model showed significant interaction between cognitive state and personality traits predicting MTL abnormality. The interaction effect was mainly driven by neuroticism and its facets (anxiety, depression, and stress) and was associated with right-left asymmetry and an anterior to posterior gradient in the MTL.

DISCUSSION
Our results support the hypothesis that personality traits can alter the vulnerability and pathoplasticity of disease and therefore modulate related biomarker expression.

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