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Regulation of TOR by small GTPases.

  • Durán RV Biozentrum, University of Basel, Klingelbergstrasse 50/70, 4056 Basel, Switzerland.
  • Hall MN
  • 2012-01-14
Published in:
  • EMBO reports. - 2012
Animals
Humans
Models, Biological
Monomeric GTP-Binding Proteins
Signal Transduction
TOR Serine-Threonine Kinases
English TOR is a conserved serine/threonine kinase that responds to nutrients, growth factors, the bioenergetic status of the cell and cellular stress to control growth, metabolism and ageing. A diverse group of small GTPases including Rheb, Rag, Rac1, RalA and Ryh1 play a variety of roles in the regulation of TOR. For example, while Rheb binds to and activates TOR directly, Rag and Rac1 regulate its localization and RalA activates it indirectly through the production of phosphatidic acid. Here, we review recent findings on the regulation of TOR by small GTPases.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/5976
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