Back
CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes.
Journal article

CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes.

  • Dimas P Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland.
  • Montani L Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland.
  • Pereira JA Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland.
  • Moreno D Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland.
  • Trötzmüller M Center for Medical Research, Medical University of Graz, Graz, Austria.
  • Gerber J Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland.
  • Semenkovich CF Division of Endocrinology, Metabolism and Lipid Research, Washington University Medical School, St. Louis, United States.
  • Köfeler HC Center for Medical Research, Medical University of Graz, Graz, Austria.
  • Suter U Institute of Molecular Health Sciences, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland.
Show more…
  • 2019-05-08
Published in:
  • eLife. - 2019
fatty acid synthesis
high fat diet
mouse
myelin lipids
myelination
neuroscience
oligodendrocytes
remyelination
Animals
Cell Differentiation
Cell Proliferation
Central Nervous System
Demyelinating Diseases
Disease Models, Animal
Fatty Acid Synthase, Type I
Fatty Acids
Mice, Transgenic
Myelin Sheath
Neural Stem Cells
Oligodendroglia
Remyelination
English Oligodendrocytes (OLs) support neurons and signal transmission in the central nervous system (CNS) by enwrapping axons with myelin, a lipid-rich membrane structure. We addressed the significance of fatty acid (FA) synthesis in OLs by depleting FA synthase (FASN) from OL progenitor cells (OPCs) in transgenic mice. While we detected no effects in proliferation and differentiation along the postnatal OL lineage, we found that FASN is essential for accurate myelination, including myelin growth. Increasing dietary lipid intake could partially compensate for the FASN deficiency. Furthermore, FASN contributes to correct myelin lipid composition and stability of myelinated axons. Moreover, we depleted FASN specifically in adult OPCs to examine its relevance for remyelination. Applying lysolecithin-induced focal demyelinating spinal cord lesions, we found that FA synthesis is essential to sustain adult OPC-derived OLs and efficient remyelination. We conclude that FA synthesis in OLs plays key roles in CNS myelination and remyelination.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/60474
Statistics
Document views: 45 File downloads: