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Multimodal gradients across mouse cortex.

  • Fulcher BD School of Physics, Sydney University, Sydney, NSW 2006, Australia; ben.fulcher@sydney.edu.au xjwang@nyu.edu.
  • Murray JD Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511.
  • Zerbi V Neural Control of Movement Laboratory, Department of Health Sciences and Technology, Eidgenössische Technische Hochschule Zürich, 8057 Zürich, Switzerland.
  • Wang XJ Center for Neural Science, New York University, New York, NY 10003; ben.fulcher@sydney.edu.au xjwang@nyu.edu.
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  • 2019-02-21
Published in:
  • Proceedings of the National Academy of Sciences of the United States of America. - 2019
cortical gradients
cortical hierarchy
gene expression
interspecies comparison
Animals
Brain Mapping
Cerebral Cortex
Gene Expression
Humans
Magnetic Resonance Imaging
Mice
Proteins
Transcription, Genetic
English The primate cerebral cortex displays a hierarchy that extends from primary sensorimotor to association areas, supporting increasingly integrated function underpinned by a gradient of heterogeneity in the brain's microcircuits. The extent to which these hierarchical gradients are unique to primate or may reflect a conserved mammalian principle of brain organization remains unknown. Here we report the topographic similarity of large-scale gradients in cytoarchitecture, gene expression, interneuron cell densities, and long-range axonal connectivity, which vary from primary sensory to prefrontal areas of mouse cortex, highlighting an underappreciated spatial dimension of mouse cortical specialization. Using the T1-weighted:T2-weighted (T1w:T2w) magnetic resonance imaging map as a common spatial reference for comparison across species, we report interspecies agreement in a range of large-scale cortical gradients, including a significant correspondence between gene transcriptional maps in mouse cortex with their human orthologs in human cortex, as well as notable interspecies differences. Our results support the view of systematic structural variation across cortical areas as a core organizational principle that may underlie hierarchical specialization in mammalian brains.
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  • English
Open access status
bronze
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https://sonar.ch/global/documents/60568
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