The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*
- Percie du Sert, Nathalie ORCID Head of Experimental Design and Reporting, NC3Rs, London, United Kingdom
- Hurst, Viki Science Manager – Experimental Design and Reporting, NC3Rs, London, United Kingdom
- Ahluwalia, Amrita Director of the Barts Cardiovascular CTU, Queen Mary University of London, London, United Kingdom
- Alam, Sabina Director of Publishing Ethics and Integrity, Taylor & Francis Group, London, United Kingdom
- Avey, Marc T. Lead Health Scientist, Health Science Practice, ICF, Durham, North Carolina, United States of America
- Baker, Monya Senior Editor, Opinion, Nature, San Francisco, California, United States of America
- Browne, William J. Professor of Statistics, School of Education, University of Bristol, Bristol, United Kingdom
- Clark, Alejandra Senior Editor, Team Manager – Life Sciences, PLOS ONE, Cambridge, United Kingdom
- Cuthill, Innes C. Professor of Behavioural Ecology, School of Biological Sciences, University of Bristol, Bristol, United Kingdom
- Dirnagl, Ulrich Director, QUEST Center for Transforming Biomedical Research, Berlin Institute of Health & Department of Experimental Neurology, Charite Universitätsmedizin Berlin, Berlin, Germany
- Emerson, Michael Reader in Platelet Pharmacology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
- Garner, Paul Professor, and Director of the Centre for Evidence Synthesis in Global Health, Clinical Sciences Department, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
- Holgate, Stephen T. MRC Clinical Professor, Clinical and Experimental Sciences, University of Southampton, Southampton, United Kingdom
- Howells, David W. Professor of Neuroscience and Brain Plasticity, Tasmanian School of Medicine, University of Tasmania, Hobart, Australia
- Karp, Natasha A. Principal Scientist – Statistician & UK Team Lead, Data Sciences & Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge, United Kingdom
- Lazic, Stanley E. Chief Scientific Officer, Prioris.ai Inc, Ottawa, Canada
- Lidster, Katie Programme Manager – Animal Welfare, NC3Rs, London, United Kingdom
- MacCallum, Catriona J. Director of Open Science, Hindawi Ltd, London, United Kingdom
- Macleod, Malcolm Academic Lead for Research Improvement and Research Integrity, University of Edinburgh, Edinburgh, United Kingdom
- Pearl, Esther J. Programme Manager – Experimental Design, NC3Rs, London, United Kingdom
- Petersen, Ole H. Director of the Academia Europaea Knowledge Hub, Cardiff University, Cardiff, United Kingdom
- Rawle, Frances Director of Policy, Ethics and Governance, Medical Research Council, London, United Kingdom
- Reynolds, Penny Biostatistician, Statistics in Anesthesiology Research (STAR) Core & Research Assistant Professor, Department of Anesthesiology College of Medicine, University of Florida, Gainesville, Florida, United States of America
- Rooney, Kieron Associate Professor, Discipline of Exercise and Sport Science, Faculty of Medicine and Health, University of Sydney, Sydney, Australia
- Sena, Emily S. Stroke Association Kirby Laing Foundation Senior Non-Clinical Lecturer, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
- Silberberg, Shai D. Director of Research Quality, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, United States of America
- Steckler, Thomas Associate Director, BRQC Animal Welfare Strategy Lead, Janssen Pharmaceutica NV, Beerse, Belgium
- Würbel, Hanno Professor for Animal Welfare, Veterinary Public Health Institute, Vetsuisse Faculty, University of Bern, Bern, Switzerland
- 2020-7-14
Published in:
- Journal of Cerebral Blood Flow & Metabolism. - SAGE Publications. - 2020, vol. 40, no. 9, p. 1769-1777
English
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the reporting of animal research. They consist of a checklist of information to include in publications describing in vivo experiments to enable others to scrutinise the work adequately, evaluate its methodological rigour, and reproduce the methods and results. Despite considerable levels of endorsement by funders and journals over the years, adherence to the guidelines has been inconsistent, and the anticipated improvements in the quality of reporting in animal research publications have not been achieved. Here, we introduce ARRIVE 2.0. The guidelines have been updated and information reorganised to facilitate their use in practice. We used a Delphi exercise to prioritise and divide the items of the guidelines into 2 sets, the “ARRIVE Essential 10,” which constitutes the minimum requirement, and the “Recommended Set,” which describes the research context. This division facilitates improved reporting of animal research by supporting a stepwise approach to implementation. This helps journal editors and reviewers verify that the most important items are being reported in manuscripts. We have also developed the accompanying Explanation and Elaboration document, which serves (1) to explain the rationale behind each item in the guidelines, (2) to clarify key concepts, and (3) to provide illustrative examples. We aim, through these changes, to help ensure that researchers, reviewers, and journal editors are better equipped to improve the rigour and transparency of the scientific process and thus reproducibility.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1177/0271678x20943823
- ISSN 0271-678X
- Persistent URL
- https://sonar.ch/global/documents/61160
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