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Regulation of MHC class II gene expression by the class II transactivator.
Journal article

Regulation of MHC class II gene expression by the class II transactivator.

  • Reith W Department of Pathology and Immunology, University of Geneva Medical School, Centre Médical Universitaire, 1 Rue Michel-Servet, CH-1211, Geneva, Switzerland. walter.reith@medecine.unige.ch
  • LeibundGut-Landmann S
  • Waldburger JM
  • 2005-10-04
Published in:
  • Nature reviews. Immunology. - 2005
Animals
Gene Expression Regulation
Genes, MHC Class II
Humans
Mice
Models, Immunological
Nuclear Proteins
Trans-Activators
English MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern. This complex gene-expression profile is controlled almost exclusively by a single master regulatory factor, which is known as the class II transactivator. As we discuss here, differential activation of the three independent promoters that drive expression of the gene encoding the class II transactivator ultimately determines the exquisitely regulated pattern of MHC class II gene expression.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/61803
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