Journal article

Cellular uptake and biocompatibility of bismuth ferrite harmonic advanced nanoparticles.

  • Staedler D Institute of Chemical Sciences and Engineering, EPFL, Batochime, 1015, Lausanne, Switzerland.
  • Passemard S Institute of Chemical Sciences and Engineering, EPFL, Batochime, 1015, Lausanne, Switzerland.
  • Magouroux T GAP-Biophotonics, Université de Genève, 22 Chemin de Pinchat, 1211 Genève 4, Switzerland.
  • Rogov A GAP-Biophotonics, Université de Genève, 22 Chemin de Pinchat, 1211 Genève 4, Switzerland.
  • Maguire CM Nanomedicine Laboratory and Molecular Imaging Group, School of Medicine, Trinity Centre for Health Sciences, Trinity College, D8, Dublin, Ireland.
  • Mohamed BM Nanomedicine Laboratory and Molecular Imaging Group, School of Medicine, Trinity Centre for Health Sciences, Trinity College, D8, Dublin, Ireland.
  • Schwung S FEE Gmbh, Struthstrasse 2, 55743 Idar-Oberstein, Germany.
  • Rytz D FEE Gmbh, Struthstrasse 2, 55743 Idar-Oberstein, Germany.
  • Jüstel T Fachbereich Chemieingenieurwesen, Fachhochschule Münster, Stegerwaldstrasse 39, 48565 Steinfurt, Germany.
  • Hwu S GAP-Biophotonics, Université de Genève, 22 Chemin de Pinchat, 1211 Genève 4, Switzerland.
  • Mugnier Y Univ. Savoie, SYMME, F-74000, Annecy, France.
  • Le Dantec R Univ. Savoie, SYMME, F-74000, Annecy, France.
  • Volkov Y Nanomedicine Laboratory and Molecular Imaging Group, School of Medicine, Trinity Centre for Health Sciences, Trinity College, D8, Dublin, Ireland; AMBER Centre and CRANN Institute, Trinity College, D2, Dublin, Ireland.
  • Gerber-Lemaire S Institute of Chemical Sciences and Engineering, EPFL, Batochime, 1015, Lausanne, Switzerland.
  • Prina-Mello A Nanomedicine Laboratory and Molecular Imaging Group, School of Medicine, Trinity Centre for Health Sciences, Trinity College, D8, Dublin, Ireland; AMBER Centre and CRANN Institute, Trinity College, D2, Dublin, Ireland.
  • Bonacina L GAP-Biophotonics, Université de Genève, 22 Chemin de Pinchat, 1211 Genève 4, Switzerland. Electronic address: luigi.bonacina@unige.ch.
  • Wolf JP GAP-Biophotonics, Université de Genève, 22 Chemin de Pinchat, 1211 Genève 4, Switzerland.
Show more…
  • 2015-02-06
Published in:
  • Nanomedicine : nanotechnology, biology, and medicine. - 2015
English UNLABELLED
Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented diagnostic applications as intra- and extra membrane contrast agents. Due to the relatively recent availability of this material in well dispersed nanometric form, its biocompatibility was not known to date. In this study, we present a thorough assessment of the effects of in vitro exposure of human adenocarcinoma (A549), lung squamous carcinoma (NCI-H520), and acute monocytic leukemia (THP-1) cell lines to uncoated and poly(ethylene glycol)-coated BFO-NP in the form of cytotoxicity, haemolytic response and biocompatibility. Our results support the attractiveness of the functional-BFO towards biomedical applications focused on advanced diagnostic imaging.


FROM THE CLINICAL EDITOR
Bismuth Ferrite nanoparticles (BFO-NP) have been recently successfully introduced as photodynamic tools and imaging probes. However, how these nanoparticles interact with various cells at the cellular level remains poorly understood. In this study, the authors performed in vitro experiments to assess the effects of uncoated and PEG-coated BFO-NP in the form of cytotoxicity, haemolytic response and biocompatibility.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/62283
Statistics

Document views: 40 File downloads:
  • fulltext.pdf: 0