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Influence of endothelial surface on flow velocity in vitro.
Journal article

Influence of endothelial surface on flow velocity in vitro.

  • 1993-08-01
Published in:
  • The American journal of physiology. - 1993
Animals
Blood
Blood Flow Velocity
Blood Viscosity
Cells, Cultured
Endothelium, Vascular
Fibrin
Fibrinogen
Humans
Microspheres
Solutions
Surface Properties
English The influence of the endothelial surface and its interaction with various plasma components on flow velocity was investigated in vitro. The falling velocity of microcarrier beads with and without cultured porcine aortic endothelial cells in a vertical tube containing different media was recorded with a video system attached to a light microscope. The falling velocity of the beads was in agreement with values predicted from Stokes's law. Endothelium did not affect the falling velocity in various media, except in plasma, where it was slower than expected. Fibrinogen was found to have a strong surface tension effect, disturbing viscosity measurements, and to bind to endothelial cells and collagen-coated surfaces. We conclude that the endothelial surface may interact with plasma and plasma constituents such as fibrinogen in a way that affects blood flow.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/63641
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