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Snake venom L-amino acid oxidases.
Journal article

Snake venom L-amino acid oxidases.

  • Du XY Theodor Kocher Institute, University of Berne, Freiestrasse 1, CH-3012 Berne, Switzerland.
  • Clemetson KJ
  • 2002-08-15
Published in:
  • Toxicon : official journal of the International Society on Toxinology. - 2002
Amino Acid Oxidoreductases
Amino Acid Sequence
Animals
L-Amino Acid Oxidase
Models, Chemical
Molecular Sequence Data
Sequence Homology, Amino Acid
Snake Venoms
Snakes
Species Specificity
English L-amino acid oxidases are widely found in snake venoms and are thought to contribute to the toxicity upon envenomation. The mechanism of these toxic effects and whether they result from the enzymatic activity are still uncertain although many papers describing the biological and pharmacological effects of L-amino acid oxidases have appeared recently, which provide more information about their action on platelets, induction of apoptosis, haemorrhagic effects, and cytotoxicity. This review summarizes the physiochemical properties, structural characteristics and various biological functions of snake venom L-amino acid oxidases (SV-LAAOs). In addition, the putative mechanisms of SV-LAAO-induced platelet aggregation and apoptosis of cells are discussed in more detail.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/6444
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