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The electrophysiology of gap junctions and gap junction channels and their mathematical modelling.
Journal article

The electrophysiology of gap junctions and gap junction channels and their mathematical modelling.

  • Vogel R Department of Cardiology, Swiss Cardiovascular Center, Inselspital, CH-3010, Bern, Switzerland.
  • Weingart R
  • 2003-02-05
Published in:
  • Biology of the cell. - 2002
Animals
Cell Membrane Permeability
Electrophysiology
Gap Junctions
Humans
Models, Theoretical
Protein Conformation
English In most tissues of vertebrates, gap junctions control the exchange of ions and small molecules between adjacent cells, thus co-ordinating the cellular activities. The application of the dual voltage-clamp method to cell pair preparations enables one to elucidate the electrical properties of gap junctions and gap junction channels. The conductive and kinetic data obtained at the multichannel and single channel level led to a generalised concept for the operation of gap junction channels. Based on the biological data gained in this way, a mathematical model has been developed. This model is versatile and allows to simulate the electrophysiological behaviour of different types of vertebrate gap junctions.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/6465
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