PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation.
- Spalinger MR Department for Gastroenterology and Hepatology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland.
- Scharl M Department for Gastroenterology and Hepatology, University Hospital Zurich, and University of Zurich, Zurich, Switzerland.
- 2018-09-26
Published in:
- Molecular & cellular oncology. - 2018
Biology of malignant cells
Biology of the tumor stroma
Colitis-associated cancer
IFN-gamma
Inflammasome
Mechanisms of oncogenesis and tumor progression
PTPN2
TC-PTP
Tumor-stroma interactions
Tyrosine Phosphatase
English
We have recently demonstrated that macrophage-specific loss of Protein tyrosine phosphatase non-receptor type 2 (PTPN2) promotes inflammasome activation, resulting in protection from colorectal cancer. Here we place these findings in context with the role of inflammasomes in colorectal carcinoma, and with a recent study indicating that PTPN2-silencing promotes anti-cancer immunotherapy.
- Language
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- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1080/23723556.2018.1465013
- PMID 30250914
- Persistent URL
- https://sonar.ch/global/documents/65399
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