Journal article
One-pot synthesis of hypervalent iodine reagents for electrophilic trifluoromethylation.
- Matoušek V Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, ETH Zürich, CH-8093 Zürich, Switzerland.
- Pietrasiak E
- Schwenk R
- Togni A
- 2013-06-06
Published in:
- The Journal of organic chemistry. - 2013
Hydrocarbons, Fluorinated
Hydrocarbons, Iodinated
Indicators and Reagents
Methylation
Molecular Structure
English
Simplified syntheses suited for large scale preparations of the two hypervalent iodine reagents 1 and 2 for electrophilic trifluoromethylation are reported. In both cases, the stoichiometric oxidants sodium metaperiodate and tert-butyl hypochlorite have been replaced by trichloroisocyanuric acid. Reagent 1 is accessible in a one-pot procedure from 2-iodobenzoic acid in 72% yield. Reagent 2 was prepared via fluoroiodane 11 in a considerably shorter reaction time and with no need of an accurate temperature control.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/jo400774u
- PMID 23734560
- Persistent URL
- https://sonar.ch/global/documents/65760
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