The contrasting phylodynamics of human influenza B viruses

Vijaykrishna, Dhanasekaran; Holmes, Edward C; Joseph, Udayan; Fourment, Mathieu; Su, Yvonne CF; Halpin, Rebecca; Lee, Raphael TC; Deng, Yi-Mo; Gunalan, Vithiagaran; Lin, Xudong; Stockwell, Timothy B; Fedorova, Nadia B; Zhou, Bin; Spirason, Natalie; Kühnert, Denise; Bošková, Veronika; Stadler, Tanja; Costa, Anna-Maria; Dwyer, Dominic E; Huang, Q Sue; Jennings, Lance C; Rawlinson, William; Sullivan, Sheena G; Hurt, Aeron C; Maurer-Stroh, Sebastian; Wentworth, David E; Smith, Gavin JD; Barr, Ian G

doi:10.7554/elife.05055

Back

Journal article

The contrasting phylodynamics of human influenza B viruses

Vijaykrishna, Dhanasekaran World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
Holmes, Edward C Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia
Joseph, Udayan Duke-NUS Graduate Medical School, Singapore, Singapore
Fourment, Mathieu Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia
Su, Yvonne CF Duke-NUS Graduate Medical School, Singapore, Singapore
Halpin, Rebecca J Craig Venter Institute, Rockville, United States
Lee, Raphael TC Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
Deng, Yi-Mo World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
Gunalan, Vithiagaran Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
Lin, Xudong J Craig Venter Institute, Rockville, United States
Stockwell, Timothy B J Craig Venter Institute, Rockville, United States
Fedorova, Nadia B J Craig Venter Institute, Rockville, United States
Zhou, Bin J Craig Venter Institute, Rockville, United States
Spirason, Natalie World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
Kühnert, Denise Department of Environmental Systems Science, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland
Bošková, Veronika Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland
Stadler, Tanja Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland
Costa, Anna-Maria Royal Children's Hospital, Parkville, Australia
Dwyer, Dominic E Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital and University of Sydney, Westmead, Australia
Huang, Q Sue Institute of Environmental Science and Research, National Centre for Biosecurity and Infectious Disease, Upper Hutt, New Zealand
Jennings, Lance C Microbiology Department, Canterbury Health Laboratories, Christchurch, New Zealand
Rawlinson, William Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia
Sullivan, Sheena G School of Population and Global Health, University of Melbourne, Melbourne, Australia
Hurt, Aeron C School of Population and Global Health, University of Melbourne, Melbourne, Australia
Maurer-Stroh, Sebastian National Public Health Laboratory, Communicable Diseases Division, Ministry of Health, Singapore, Singapore
Wentworth, David E J Craig Venter Institute, Rockville, United States
Smith, Gavin JD Duke Global Health Institute, Duke University, Durham, United States
Barr, Ian G School of Applied Sciences and Engineering, Monash University, Churchill, Australia

2015-1-16

Published in:

eLife. - eLife Sciences Publications, Ltd. - 2015, vol. 4

General Biochemistry, Genetics and Molecular Biology

General Immunology and Microbiology

English A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.

Language