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The contrasting phylodynamics of human influenza B viruses
Journal article

The contrasting phylodynamics of human influenza B viruses

  • Vijaykrishna, Dhanasekaran World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
  • Holmes, Edward C Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia
  • Joseph, Udayan Duke-NUS Graduate Medical School, Singapore, Singapore
  • Fourment, Mathieu Marie Bashir Institute for Infectious Diseases and Biosecurity, University of Sydney, Sydney, Australia
  • Su, Yvonne CF Duke-NUS Graduate Medical School, Singapore, Singapore
  • Halpin, Rebecca J Craig Venter Institute, Rockville, United States
  • Lee, Raphael TC Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
  • Deng, Yi-Mo World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
  • Gunalan, Vithiagaran Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Singapore
  • Lin, Xudong J Craig Venter Institute, Rockville, United States
  • Stockwell, Timothy B J Craig Venter Institute, Rockville, United States
  • Fedorova, Nadia B J Craig Venter Institute, Rockville, United States
  • Zhou, Bin J Craig Venter Institute, Rockville, United States
  • Spirason, Natalie World Health Organisation Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Australia
  • Kühnert, Denise Department of Environmental Systems Science, Eidgenössische Technische Hochschule Zürich, Zürich, Switzerland
  • Bošková, Veronika Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland
  • Stadler, Tanja Department of Biosystems Science and Engineering, Eidgenössische Technische Hochschule Zürich, Zurich, Switzerland
  • Costa, Anna-Maria Royal Children's Hospital, Parkville, Australia
  • Dwyer, Dominic E Centre for Infectious Diseases and Microbiology Laboratory Services, Westmead Hospital and University of Sydney, Westmead, Australia
  • Huang, Q Sue Institute of Environmental Science and Research, National Centre for Biosecurity and Infectious Disease, Upper Hutt, New Zealand
  • Jennings, Lance C Microbiology Department, Canterbury Health Laboratories, Christchurch, New Zealand
  • Rawlinson, William Virology Division, SEALS Microbiology, Prince of Wales Hospital, Sydney, Australia
  • Sullivan, Sheena G School of Population and Global Health, University of Melbourne, Melbourne, Australia
  • Hurt, Aeron C School of Population and Global Health, University of Melbourne, Melbourne, Australia
  • Maurer-Stroh, Sebastian National Public Health Laboratory, Communicable Diseases Division, Ministry of Health, Singapore, Singapore
  • Wentworth, David E J Craig Venter Institute, Rockville, United States
  • Smith, Gavin JD Duke Global Health Institute, Duke University, Durham, United States
  • Barr, Ian G School of Applied Sciences and Engineering, Monash University, Churchill, Australia
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  • 2015-1-16
Published in:
  • eLife. - eLife Sciences Publications, Ltd. - 2015, vol. 4
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology
General Neuroscience
General Medicine
English A complex interplay of viral, host, and ecological factors shapes the spatio-temporal incidence and evolution of human influenza viruses. Although considerable attention has been paid to influenza A viruses, a lack of equivalent data means that an integrated evolutionary and epidemiological framework has until now not been available for influenza B viruses, despite their significant disease burden. Through the analysis of over 900 full genomes from an epidemiological collection of more than 26,000 strains from Australia and New Zealand, we reveal fundamental differences in the phylodynamics of the two co-circulating lineages of influenza B virus (Victoria and Yamagata), showing that their individual dynamics are determined by a complex relationship between virus transmission, age of infection, and receptor binding preference. In sum, this work identifies new factors that are important determinants of influenza B evolution and epidemiology.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/65830
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