Programmed genome rearrangements in ciliates.
- Rzeszutek I Institute of Biology and Biotechnology, Department of Biotechnology, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland. iwona.rzeszutek89@gmail.com.
- Maurer-Alcalá XX Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland.
- Nowacki M Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland. mariusz.nowacki@izb.unibe.ch.
- 2020-05-29
Published in:
- Cellular and molecular life sciences : CMLS. - 2020
Ciliates
DNA elimination
Genome rearrangement
Nuclear dimorphism
Small non-coding RNAs
Animals
Cell Nucleus
Ciliophora
Gene Rearrangement
Genome, Protozoan
Germ Cells
Humans
English
Ciliates are a highly divergent group of unicellular eukaryotes with separate somatic and germline genomes found in distinct dimorphic nuclei. This characteristic feature is tightly linked to extremely laborious developmentally regulated genome rearrangements in the development of a new somatic genome/nuclei following sex. The transformation from germline to soma genome involves massive DNA elimination mediated by non-coding RNAs, chromosome fragmentation, as well as DNA amplification. In this review, we discuss the similarities and differences in the genome reorganization processes of the model ciliates Paramecium and Tetrahymena (class Oligohymenophorea), and the distantly related Euplotes, Stylonychia, and Oxytricha (class Spirotrichea).
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1007/s00018-020-03555-2
- PMID 32462406
- Persistent URL
- https://sonar.ch/global/documents/67107
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