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Journal article

Murine adenoviruses: tools for studying adenovirus pathogenesis in a natural host.

  • Hemmi S Institute of Molecular Life Sciences, University of Zürich, Switzerland.
  • Spindler KR Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
  • 2019-11-29
Published in:
  • FEBS letters. - 2019
Ly6
PKR
adenovirus vaccines
adenovirus vectors
alpha-defensins
host susceptibility to viruses
immunoproteasome
mouse adenovirus
viral pathogenesis
Adenoviridae Infections
Animals
Gene Expression Regulation, Viral
Host-Pathogen Interactions
Mastadenovirus
Mice
Species Specificity
Viral Proteins
Viral Tropism
English Small laboratory animals are powerful models for investigating in vivo viral pathogenesis of a number of viruses. For adenoviruses (AdVs), however, species-specificity poses limitations to studying human adenoviruses (HAdVs) in mice and other small laboratory animals. Thus, this review covers work on naturally occurring mouse AdVs, primarily mouse adenovirus type 1 (MAdV-1), a member of the species Murine mastadenovirus A. Molecular genetics, virus life cycle, cell and tissue tropism, interactions with the host immune response, persistence, and host genetics of susceptibility are described. A brief discussion of MAdV-2 (member of species Murine mastadenovirus B) and MAdV-3 (member of species Murine mastadenovirus C) is included. We report the use of MAdVs in the development of vectors and vaccines.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/67405
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