Journal article
Synthesis of novel angular spirocyclic azetidines.
- Guérot C Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.
- Tchitchanov BH
- Knust H
- Carreira EM
- 2011-01-18
Published in:
- Organic letters. - 2011
English
The syntheses of a variety of novel angular azaspiro[3.3]heptanes are reported. gem-Difluoro and gem-dimethyl variants of the angular 1,6-diazaspiro[3.3]heptane module were prepared in high yields using efficient sequences. Additionally, a practical one-pot synthesis of 5-oxo-2-azaspiro[3.3]heptanes and subsequent conversions into functionalized derivatives are described. The methods reported are amenable to the synthesis of these building blocks for drug discovery as members of a library or individually on a preparative scale.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1021/ol103050c
- PMID 21235246
- Persistent URL
- https://sonar.ch/global/documents/67934
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