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Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury.
Journal article

Programming Hippocampal Neural Stem/Progenitor Cells into Oligodendrocytes Enhances Remyelination in the Adult Brain after Injury.

  • Braun SM Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH, 8057 Zurich, Switzerland.
  • Pilz GA Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH, 8057 Zurich, Switzerland.
  • Machado RA Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland.
  • Moss J Department of Fundamental Neurosciences, University of Lausanne, 1015 Lausanne, Switzerland.
  • Becher B Neuroscience Center Zurich, University of Zurich and ETH, 8057 Zurich, Switzerland; Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland.
  • Toni N Department of Fundamental Neurosciences, University of Lausanne, 1015 Lausanne, Switzerland.
  • Jessberger S Brain Research Institute, Faculty of Medicine and Science, University of Zurich, 8057 Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH, 8057 Zurich, Switzerland. Electronic address: jessberger@hifo.uzh.ch.
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  • 2015-06-16
Published in:
  • Cell reports. - 2015
Animals
Basic Helix-Loop-Helix Transcription Factors
Brain Injuries
Demyelinating Diseases
Diphtheria Toxin
Hippocampus
Mice
Mice, Inbred C57BL
Myelin Sheath
Neural Stem Cells
Neurogenesis
English Demyelinating diseases are characterized by a loss of oligodendrocytes leading to axonal degeneration and impaired brain function. Current strategies used for the treatment of demyelinating disease such as multiple sclerosis largely rely on modulation of the immune system. Only limited treatment options are available for treating the later stages of the disease, and these treatments require regenerative therapies to ameliorate the consequences of oligodendrocyte loss and axonal impairment. Directed differentiation of adult hippocampal neural stem/progenitor cells (NSPCs) into oligodendrocytes may represent an endogenous source of glial cells for cell-replacement strategies aiming to treat demyelinating disease. Here, we show that Ascl1-mediated conversion of hippocampal NSPCs into mature oligodendrocytes enhances remyelination in a diphtheria-toxin (DT)-inducible, genetic model for demyelination. These findings highlight the potential of targeting hippocampal NSPCs for the treatment of demyelinated lesions in the adult brain.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/68235
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