Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.

• Schmidt AF Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK. amand.schmidt@ucl.ac.uk.
• Holmes MV Medical Research Council Population Health Research Unit, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• Preiss D Medical Research Council Population Health Research Unit, Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
• Swerdlow DI Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
• Denaxas S UCL's BHF Research Accelerator Centre, London, UK.
• Fatemifar G UCL's BHF Research Accelerator Centre, London, UK.
• Faraway R Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
• Finan C Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
• Valentine D UCL's BHF Research Accelerator Centre, London, UK.
• Fairhurst-Hunter Z Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK.
• Hartwig FP Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
• Horta BL Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
• Hypponen E Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia.
• Power C Population, Policy and Practice, UCL GOS Institute of Child Health, London, UK.
• Moldovan M South Australian Health and Medical Research Institute, Adelaide, Australia.
• van Iperen E Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands.
• Hovingh K Department of vascular medicine, Academic Medical Center Amsterdam, Amsterdam, the Netherlands.
• Demuth I Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.
• Norman K Institute of Nutritional Science, University of Potsdam, 14558, Nuthetal, Germany.
• Steinhagen-Thiessen E Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Lipid Clinic at the Interdisciplinary Metabolism Center, Berlin, Germany.
• Demuth J E.CA Economics GmbH, Berlin, Germany.
• Bertram L Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.
• Lill CM Genetic and Molecular Epidemiology Group, Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics & Cardiogenetics, University of Lübeck, Lübeck, Germany.
• Coassin S Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, 6020, Innsbruck, Austria.
• Willeit J Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
• Kiechl S Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
• Willeit K Department of Neurology, Medical University Innsbruck, Innsbruck, Austria.
• Mason D Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
• Wright J Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
• Morris R Department Primary Care & Population Health, University College London, London, UK.
• Wanamethee G Department Primary Care & Population Health, University College London, London, UK.
• Whincup P Population Health Research Institute, St George's, University of London, London, UK.
• Ben-Shlomo Y Population Health Sciences, University of Bristol, Bristol, UK.
• McLachlan S Centre for Population Health Sciences, The Usher Institute, University of Edinburgh, Edinburgh, UK.
• Price JF Centre for Population Health Sciences, The Usher Institute, University of Edinburgh, Edinburgh, UK.
• Kivimaki M Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, UK.
• Welch C Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, UK.
• Sanchez-Galvez A Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, UK.
• Marques-Vidal P Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
• Nicolaides A Department of Vascular Surgery, Imperial College, London, United Kingdom.
• Panayiotou AG Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.
• Onland-Moret NC Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
• van der Schouw YT Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
• Matullo G Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
• Fiorito G Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
• Guarrera S Italian Institute for Genomic Medicine (IIGM), Turin, Italy.
• Sacerdote C Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy.
• Wareham NJ MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK.
• Langenberg C MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK.
• Scott RA MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK.
• Luan J MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Addenbrooke's Hospital, Cambridge, UK.
• Bobak M Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, UK.
• Malyutina S Novosibirsk State Medical University, Novosibirsk, Russian Federation.
• Pająk A Department of Epidemiology and Population Studies, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland.
• Kubinova R National Institute of Public Health, Prague, Czech Republic.
• Tamosiunas A Lithuanian University of Health Sciences, Kaunas, Lithuania.
• Pikhart H Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, London, UK.
• Grarup N Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• Pedersen O Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• Hansen T Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• Linneberg A Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
• Jess T Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, The Capital Region of Denmark, Denmark.
• Cooper J Centre for Cardiovascular Genetics, Department of Medicine, University College London, London, UK.
• Humphries SE Centre for Cardiovascular Genetics, Department of Medicine, University College London, London, UK.
• Brilliant M Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, USA.
• Kitchner T Center for Human Genetics, Marshfield Clinic Research Institute, Marshfield, USA.
• Hakonarson H Children's Hospital of Philadelphia, Philadelphia, USA.
• Carrell DS Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
• McCarty CA University of Minnesota, Minneapolis, USA.
• Lester KH Geisinger, Danville, USA.
• Larson EB Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
• Crosslin DR Department of Biomedical Informatics and Medical Education University of Washington Seattle, Seattle, WA, USA.
• de Andrade M Mayo Clinic, Rochester, USA.
• Roden DM Department of Medicine, Department of Pharmacology, Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
• Denny JC Vanderbilt University, Nashville, USA.
• Carty C WHI, Seattle, USA.
• Hancock S University of Newcastle, Newcastle, NSW, Australia.
• Attia J University of Newcastle, Newcastle, NSW, Australia.
• Holliday E University of Newcastle, Newcastle, NSW, Australia.
• Scott R University of Newcastle, Newcastle, NSW, Australia.
• Schofield P Hunter New England Local Health District, Newcastle, NSW, Australia.
• O'Donnell M Population Health Research Institute, Hamilton, Ontario, Canada.
• Yusuf S Population Health Research Institute, Hamilton, Ontario, Canada.
• Chong M Population Health Research Institute, Hamilton, Ontario, Canada.
• Pare G Population Health Research Institute, Hamilton, Ontario, Canada.
• van der Harst P Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands.
• Said MA Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Eppinga RN Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Verweij N Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
• Snieder H Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
• Christen T Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
• Mook-Kanamori DO Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
• Gustafsson S Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden.
• Lind L Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
• Ingelsson E Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
• Pazoki R Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
• Franco O Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
• Hofman A Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
• Uitterlinden A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
• Dehghan A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
• Teumer A DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
• Baumeister S Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany.
• Dörr M DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
• Lerch MM Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
• Völker U Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, Scotland, UK.
• Völzke H Institute of Health and Wellbeing, University of Glasgow, Glasgow, G12 8RZ, Scotland, UK.
• Ward J Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
• Pell JP The Department of Medical Research, Bærum Hospital, Vestre Viken Hospital Trust, Gjettum, Norway.
• Meade T Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands.
• Christophersen IE Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
• Maitland-van der Zee AH Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
• Baranova EV Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
• Young R Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
• Ford I Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
• Campbell A Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.
• Padmanabhan S Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.
• Bots ML CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, 59000, Lille, France.
• Grobbee DE CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, 59000, Lille, France.
• Froguel P INSERM, U-1138, Centre de Recherche des Cordeliers, Paris, France.
• Thuillier D CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, 59000, Lille, France.
• Roussel R l'institut du Thorax, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.
• Bonnefond A Institute for Social and Economic Research, University of Essex, Essex, UK.
• Cariou B Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England.
• Smart M Boston University School of Medicine, Boston, MA, USA.
• Bao Y Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, England.
• Kumari M Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Richard Doll Building, Old Road Campus, Roosevelt Drive, Oxford, OX3 7LF, UK.
• Mahajan A Boston University School of Medicine, Boston, MA, USA.
• Hopewell JC University College London, Farr Institute of Health Informatics, London, UK.
• Seshadri S University College London, Farr Institute of Health Informatics, London, UK.
• Dale C Harvard Medical School Center for Cardiovascular Disease Prevention Brigham and Women's Hospital, Boston, USA.
• Costa RPE UWash, Seattle, USA.
• Ridker PM Penn State, State College, USA.
• Chasman DI University of Colorado Denver, Denver, USA.
• Reiner AP Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Ritchie MD Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Lange LA Div. Molecular Genetic Epidemiology German Cancer Research Center, Im Neuenheimer Feld 580, 69120, Heidelberg, Germany.
• Cornish AJ Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Dobbins SE The Institut du Cerveau et de la Moelle épinière - ICM, Paris, France.
• Hemminki K The Institut du Cerveau et de la Moelle épinière - ICM, Paris, France.
• Kinnersley B Department of Neurosurgery, Bethel Clinic, Kantensiek 11, 33617, Bielefeld, Germany.
• Sanson M Division of Hematology-Oncology, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas, 77030, USA.
• Labreche K Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Simon M Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Bondy M Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK.
• Law P Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Speedy H Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Allan J Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA.
• Li N Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, USA.
• Went M Department of Hematology, Erasmus MC Cancer Institute, 3075 EA, Rotterdam, the Netherlands.
• Weinhold N Hematology and Transfusion Medicine, Department of Laboratory Medicine, BMC B13, SE-221 84, Lund, Sweden.
• Morgan G University Clinic Heidelberg, Internal Medicine V and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
• Sonneveld P Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Nilsson B Department of Internal Medicine, University Hospital of Cologne, Cologne, Germany.
• Goldschmidt H Hematology Clinic, Skåne University Hospital, Skåne, Sweden.
• Sud A UCL's BHF Research Accelerator Centre, London, UK.
• Engert A Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
• Hansson M Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
• Hemingway H UPenn, Philadelphia, USA.
• Asselbergs FW Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.
• Patel RS Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
• Keating BJ Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) Veterans Affairs Boston Healthcare System, Boston, USA.
• Sattar N Institute of Cardiovascular Science, University College London, 222 Euston Road, London, NW1 2DA, UK.
• Houlston R
• Casas JP
• Hingorani AD

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Genetic association studies

LDL-cholesterol

Mendelian randomisation

Phenome-wide association scan

Anticholesteremic Agents

Biomarkers

Brain Ischemia

Cholesterol, LDL

Down-Regulation

Dyslipidemias

Genome-Wide Association Study

Humans

Myocardial Infarction

Polymorphism, Single Nucleotide

Proprotein Convertase 9

Randomized Controlled Trials as Topic

Risk Assessment

Risk Factors

Serine Proteinase Inhibitors

Stroke

Treatment Outcome