Back
Full-text
Journal article

The synthesis and antiproliferative activities of new arylidene-hydrazinyl-thiazole derivatives.

  • Grozav A Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Victor Babes 41, RO-400012 Cluj-Napoca, Romania. adriana.ignat@umfcluj.ro.
  • Găină LI Faculty of Chemistry and Chemical Engineering, University "Babes-Bolyai", M. Kogalniceanu 1, RO-400028 Cluj-Napoca. gluiza@chem.ubbcluj.ro.
  • Pileczki V Research Center of Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Marinescu 23, RO-400337 Cluj-Napoca, Romania. valentinapilecki@gmail.com.
  • Crisan O Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Victor Babes 41, RO-400012 Cluj-Napoca, Romania. ocrisan@umfcluj.ro.
  • Silaghi-Dumitrescu L Faculty of Chemistry and Chemical Engineering, University "Babes-Bolyai", M. Kogalniceanu 1, RO-400028 Cluj-Napoca. lusi@chem.ubbcluj.ro.
  • Therrien B Institut de Chimie, Université de Neuchâtel, Avenue de Bellevaux 51, CH-2000 Neuchâtel, Switzerland. bruno.therrien@unine.ch.
  • Zaharia V Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Victor Babes 41, RO-400012 Cluj-Napoca, Romania. vzaharia@umfcluj.ro.
  • Berindan-Neagoe I Research Center of Functional Genomics, Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Marinescu 23, RO-400337 Cluj-Napoca, Romania. ioananeagoe29@gmail.com.
Show more…
  • 2014-12-04
Published in:
  • International journal of molecular sciences. - 2014
Cell Death
Cell Proliferation
Cell Survival
DNA
Drug Screening Assays, Antitumor
HeLa Cells
Humans
Hydrazines
Inhibitory Concentration 50
Intercalating Agents
Thiazoles
English New and known arylidene-hydrazinyl-thiazole derivatives have been synthesized by a convenient Hantzsch condensation. All compounds were evaluated for their in vitro cytotoxicity on two carcinoma cell lines, MDA-MB231 and HeLa. Significant antiproliferative activity for 2-(2-benzyliden-hydrazinyl)-4-methylthiazole on both MDA-MB-231 (IC50: 3.92 µg/mL) and HeLa (IC50: 11.4 µg/mL) cell lines, and for 2-[2-(4-methoxybenzylidene) hydrazinyl]-4-phenylthiazole on HeLa (IC50: 11.1 µg/mL) cell line is reported. Electrophoresis experiments showed no plasmid DNA (pTZ57R) cleavage in the presence of the investigated thiazoles.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/693
Statistics
Document views: 31 File downloads:
  • Full-text: 0