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Engineering antigen-specific immunological tolerance.
Journal article

Engineering antigen-specific immunological tolerance.

  • Kontos S Anokion SA, Ecublens, Switzerland. Electronic address: stephan@anokion.com.
  • Grimm AJ Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
  • Hubbell JA Anokion SA, Ecublens, Switzerland; Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; Institute for Molecular Engineering, University of Chicago, Chicago, IL, USA; Materials Science Division, Argonne National Laboratory, Argonne, IL, USA. Electronic address: jeffrey.hubbell@epfl.ch.
  • 2015-07-12
Published in:
  • Current opinion in immunology. - 2015
Animals
Antigen Presentation
Apoptosis
B-Lymphocytes
Epitopes
Humans
Peripheral Tolerance
Protein Engineering
Receptor Cross-Talk
Receptors, Antigen, B-Cell
T-Cell Antigen Receptor Specificity
T-Lymphocytes
English Unwanted immunity develops in response to many protein drugs, in autoimmunity, in allergy, and in transplantation. Approaches to induce immunological tolerance aim to either prevent these responses or reverse them after they have already taken place. We present here recent developments in approaches, based on engineered peptides, proteins and biomaterials, that harness mechanisms of peripheral tolerance both prophylactically and therapeutically to induce antigen-specific immunological tolerance. These mechanisms are based on responses of B and T lymphocytes to other cells in their immune environment that result in cellular deletion or ignorance to particular antigens, or in development of active immune regulatory responses. Several of these approaches are moving toward clinical development, and some are already in early stages of clinical testing.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/69704
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