Cytokines of the IL-17 family in psoriasis.

Lauffer F; Eyerich K; Boehncke WH; Asadullah K; Beissert S; Ghoreschi K; Schön MP

doi:10.1111/ddg.14124

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Journal article

Cytokines of the IL-17 family in psoriasis.

Lauffer F Department of Dermatology and Allergy Biederstein, University hospital of the Technical University Munich (TUM), Munich, Germany.
Eyerich K Department of Dermatology and Allergy Biederstein, University hospital of the Technical University Munich (TUM), Munich, Germany.
Boehncke WH Division of Dermatology and Venereology and Department of Pathology and Immunology, University Hospital of Geneva, University of Geneva, Geneva, Switzerland.
Asadullah K Dermatology practice Potsdam, Potsdam, Germany.
Beissert S Department of Dermatology, Carl Gustav Carus University Medical Center, Dresden Technical University, Dresden, Germany.
Ghoreschi K Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Schön MP Department of Dermatology, Venereology and Allergology, University Medical Center, Göttingen University, Göttingen, Germany.

2020-05-25

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Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG. - 2020

Antibodies, Monoclonal, Humanized

English Various immune cells and their messenger substances influence the development of psoriasis. Cytokines of the IL-17 family are of particular importance. In addition to IL-17A, which plays a central role in the pathogenesis of psoriasis, other subtypes of the IL-17 family also have a proinflammatory effect. This review provides an up-to-date overview of the immunopathogenesis of psoriasis with regard to the six IL-17 subtypes, in particular their physiological and pathogenic properties, as well as their significance for psoriasis therapy.

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