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Journal article

Bacterial meningitis impairs hippocampal neurogenesis.

  • 2011-09-23
Published in:
  • Journal of neuropathology and experimental neurology. - 2011
Amino Acid Chloromethyl Ketones
Analysis of Variance
Animals
Animals, Newborn
Annexin A5
Apoptosis
Cell Differentiation
Cells, Cultured
Collagen
Disease Models, Animal
Gene Expression Regulation
Hippocampus
Intercellular Signaling Peptides and Proteins
Meningitis, Bacterial
Nerve Tissue Proteins
Neural Stem Cells
Neurogenesis
Neurons
Neuroprotective Agents
Rats
Rats, Wistar
Time Factors
Tumor Necrosis Factor-alpha
English Bacterial meningitis causes persisting neurofunctional sequelae. Theoccurrence of apoptotic cell death in the hippocampal subgranular zone of the dentate gyrus characterizes the disease in patients and relates to deficits in learning and memory in corresponding experimental models. Here, we investigated why neurogenesis fails to regenerate the damage in the hippocampus associated with the persistence of neurofunctional deficits. In an infant rat model of bacterial meningitis, the capacity of hippocampal-derived cells to multiply and form neurospheres was significantly impaired comparedto that in uninfected littermates. In an in vitro model of differentiating hippocampal cells, challenges characteristic of bacterial meningitis (i.e. bacterial components, tumor necrosis factor [20 ng/mL], or growth factor deprivation) caused significantly more apoptosis in stem/progenitor cells and immature neurons than in mature neurons. These results demonstrate that bacterial meningitis injures hippocampal stem and progenitor cells, a finding that may explain the persistence of neurofunctional deficits after bacterial meningitis.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/71201
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