DNA-encoded chemical libraries.

Scheuermann J; Dumelin CE; Melkko S; Neri D

doi:10.1016/j.jbiotec.2006.05.018

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Journal article

DNA-encoded chemical libraries.

Scheuermann J Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zurich, Switzerland.
Dumelin CE
Melkko S
Neri D

2006-07-25

Published in:

Journal of biotechnology. - 2006

Combinatorial Chemistry Techniques

English The discovery and development of novel drugs for the multitude of targets originating from functional genomic research is a challenging task. While antibodies can nowadays be raised against virtually any given target using phage-display methodologies, a similar "selection/amplification" approach for the facile discovery of low-molecular weight compounds capable of specific binding to protein targets of choice has so far been lacking. The development of DNA-encoded chemical libraries, combined with suitable selection and high-throughput sequencing strategies, holds promises to fill this gap. Here, we review the latest developments in the field of DNA-encoded chemical libraries, commenting on the challenges and opportunities for the different experimental strategies in this rapidly evolving research area, which may gain importance for the future drug discovery process.

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