Journal article
Structure of serum response factor core bound to DNA.
- Pellegrini L Institut für Molekularbiologie und Biophysik, ETH-Hönggerberg, Zürich, Switzerland.
- Tan S
- Richmond TJ
- 1995-08-10
Published in:
- Nature. - 1995
Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Computer Graphics
Crystallography, X-Ray
DNA
DNA-Binding Proteins
Humans
Minichromosome Maintenance 1 Protein
Molecular Sequence Data
Nuclear Proteins
Nucleic Acid Conformation
Protein Binding
Protein Conformation
Recombinant Proteins
Regulatory Sequences, Nucleic Acid
Serum Response Factor
Transcription Factors
English
The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1038/376490a0
- PMID 7637780
- Persistent URL
- https://sonar.ch/global/documents/71715
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