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Dealing with damage: plasma membrane repair mechanisms.
Journal article

Dealing with damage: plasma membrane repair mechanisms.

  • Draeger A Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstr. 2, 3012 Bern, Switzerland. Electronic address: draeger@ana.unibe.ch.
  • Schoenauer R Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstr. 2, 3012 Bern, Switzerland.
  • Atanassoff AP Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstr. 2, 3012 Bern, Switzerland.
  • Wolfmeier H Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstr. 2, 3012 Bern, Switzerland.
  • Babiychuk EB Department of Cell Biology, Institute of Anatomy, University of Bern, Baltzerstr. 2, 3012 Bern, Switzerland.
  • 2014-09-04
Published in:
  • Biochimie. - 2014
Annexins
Blebbing
Calcium
Microvesicle
P2X7R
Animals
Calcium
Cell Membrane
Cell-Derived Microparticles
Endocytosis
Exocytosis
Humans
Lipid Bilayers
Lysosomes
Models, Biological
English Eukaryotic cells have developed repair mechanisms, which allow them to reseal their membrane in order to prevent the efflux of cytoplasmic constituents and the uncontrolled influx of calcium. After injury, the Ca(2+)-concentration gradient fulfils a dual function: it provides guidance cues for the repair machinery and directly activates the molecules, which have a repair function. Depending on the nature of injury, the morphology of the cell and the severity of injury, the membrane resealing can be effected by lysosomal exocytosis, microvesicle shedding or a combination of both. Likewise, exocytosis is often followed by the endocytic uptake of lesions. Additionally, since plasmalemmal resealing must be attempted, even after extensive injury in order to prevent cell lysis, the restoration of membrane integrity can be achieved by ceramide-driven invagination of the lipid bilayer, during which the cell is prepared for apoptotic disposal. Plasmalemmal injury can be contained by a surfeit of plasma membrane, which serves as a trap for toxic substances: either passively by an abundance of cellular protrusions, or actively by membrane blebbing.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/7218
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