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Journal article

Polymeric anti-HIV therapeutics.

  • Danial M École Polytechnique Fédérale de Lausanne (EPFL), Institut des Matériaux and Institut des Sciences et Ingénierie Chimiques, Laboratoire des Polymères Bâtiment MXD, Station 12, Lausanne, CH-1015, Switzerland. Maarten.Danial@csiro.au.
  • Klok HA
  • 2014-09-05
Published in:
  • Macromolecular bioscience. - 2015
HIV polymer therapeutics
antiviral
inhibitor
microbicide
polyvalency
Anti-Retroviral Agents
Cell Adhesion Molecules
HIV Infections
HIV-1
Humans
Integrase Inhibitors
Lectins, C-Type
Molecular Structure
Polymers
Receptors, Cell Surface
Reverse Transcription
Virus Internalization
English The scope of this review is to highlight the application of polymer therapeutics in an effort to curb the transmission and infection of the human immunodeficiency virus (HIV). Following a description of the HIV life cycle, the use of approved antiretroviral drugs that inhibit critical steps in the HIV infection process is highlighted. After that, a comprehensive overview of the structure and inhibitory properties of polymeric anti-HIV therapeutic agents is presented. This overview will include inhibitors based on polysaccharides, synthetic polymers, dendritic polymers, polymer conjugates as well as polymeric DC-SIGN antagonists. The review will conclude with a section that discusses the applications of polymers and polymer conjugates as systemic and topical anti-HIV therapeutics.
Language
  • English
Open access status
bronze
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Persistent URL
https://sonar.ch/global/documents/72442
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