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Nucleosome remodelers in double-strand break repair.
Journal article

Nucleosome remodelers in double-strand break repair.

  • Seeber A Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
  • Hauer M
  • Gasser SM
  • 2013-01-29
Published in:
  • Current opinion in genetics & development. - 2013
Adenosine Triphosphate
Chromatin Assembly and Disassembly
DNA Breaks, Double-Stranded
DNA Repair
DNA-Binding Proteins
Histones
Nucleosomes
Phosphorylation
Rad51 Recombinase
Saccharomyces cerevisiae
English ATP-dependent nucleosome remodelers use ATP hydrolysis to shift, evict and exchange histone dimers or octamers and have well-established roles in transcription. Earlier work has suggested a role for nucleosome remodelers such as INO80 in double-strand break (DSB) repair. This review will begin with an update on recent studies that explore how remodelers are recruited to DSBs. We then examine their impact on various steps of repair, focusing on resection and the formation of the Rad51-ssDNA nucleofilament. Finally, we will explore new studies that implicate remodelers in the physical movement of chromatin in response to damage.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/72767
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