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PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.
Journal article

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.

  • Grossen P Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Witzigmann D Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Sieber S Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Huwyler J Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland. Electronic address: joerg.huwyler@unibas.ch.
  • 2017-05-25
Published in:
  • Journal of controlled release : official journal of the Controlled Release Society. - 2017
Drug delivery
Drug targeting
Nanomedicine
Nanoparticle
Peg-PCL
Polymer
Animals
Drug Delivery Systems
Drug Liberation
Drug Stability
Humans
Nanomedicine
Nanoparticles
Polyesters
Polyethylene Glycols
English The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug delivery systems based on poly(ethylene glycol)-poly(ε-caprolactone) copolymers (PEG-PCL) represent a strategy to implement therapies with enhanced drug accumulation at the site of action and decreased off-target effects. In this review, we discuss state-of-the-art nanomedicines based on PEG-PCL that have been investigated in a preclinical setting. We summarize the various synthesis routes and different preparation methods used for the production of PEG-PCL nanoparticles. Additionally, we review physico-chemical properties including biodegradability, biocompatibility, and drug loading. Finally, we highlight recent therapeutic applications investigated in vitro and in vivo using advanced systems such as triggered release, multi-component therapies, theranostics, or gene delivery systems.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/73128
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