Back
Mechanisms of cyclic-di-GMP signaling in bacteria.
Journal article

Mechanisms of cyclic-di-GMP signaling in bacteria.

  • Jenal U Biozentrum of the University of Basel, CH-4056 Basel, Switzerland. urs.jenal@unibas.ch
  • Malone J
  • 2006-08-10
Published in:
  • Annual review of genetics. - 2006
Bacteria
Caulobacter crescentus
Cyclic GMP
Escherichia coli Proteins
Gluconacetobacter xylinus
Glucose
Phosphoric Diester Hydrolases
Phosphorus-Oxygen Lyases
Protein Structure, Tertiary
Pseudomonas
Second Messenger Systems
Structure-Activity Relationship
Vibrio cholerae
English Cyclic-di-GMP is a ubiquitous second messenger in bacteria. The recent discovery that c-di-GMP antagonistically controls motility and virulence of single, planktonic cells on one hand and cell adhesion and persistence of multicellular communities on the other has spurred interest in this regulatory compound. Cellular levels of c-di-GMP are controlled through the opposing activities of diguanylate cyclases and phosphodiesterases, which represent two large families of output domains found in bacterial one- and two-component systems. This review concentrates on structural and functional aspects of diguanylate cyclases and phosphodiesterases, and on their role in transmitting environmental stimuli into a range of different cellular functions. In addition, we examine several well-established model systems for c-di-GMP signaling, including Pseudomonas, Vibrio, Caulobacter, and Salmonella.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/73522
Statistics
Document views: 100 File downloads: