Retrospective Study of Salinomycin Toxicosis in 66 Cats
- Pakozdy, Akos Department for Companion Animals and Horses, Small Animal Clinic, University of Veterinary Medicine Vienna, 1210 Vienna, Veterinaerplatz 1, Austria
- Challande-Kathman, Iris Division of Animal Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, Switzerland
- Doherr, Marcus Division of Animal Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, Switzerland
- Cizinauskas, Sigitas Department of Clinical Veterinary Sciences, University of Helsinki, Virtatie 9, 01600 Vantaa, Finland
- Wheeler, Simon J. Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
- Oevermann, Anna Division of Animal Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, Switzerland
- Jaggy, Andre Division of Animal Neurology, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bremgartenstrasse 109a, 3012 Bern, Switzerland
Published in:
- Veterinary Medicine International. - Hindawi Limited. - 2010, vol. 2010, p. 1-5
English
We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes. Pathological electrodiagnostic findings: fibrillation potentials and positive sharp waves were detected in 10 cases, motor nerve conductance velocity was mildly decreased in 8/12 cats, and sensory nerve conductance velocity and repetitive nerve stimulation were normal in all examined cases. In five cases the peripheral neuropathy was confirmed by pathohistology. Fluid therapy and supportive care were used as therapy and 52 cats recovered completely. The probability for complete remission was significantly different between mildly and severely affected cases. It seems that the severity of clinical signs and prognosis correlate well with the amount of toxin ingested. We conclude that early recognition and decontamination combined with supportive care results in complete recovery.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.4061/2010/147142
- ISSN 2042-0048
- Persistent URL
- https://sonar.ch/global/documents/73857
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