A Swiss database and biobank to better understand and manage congenital lung anomalies.

Vidal I; Wildhaber BE; Moehrlen U; Regamey N; Trachsel D; Cholewa D; Barben J; Barazzone-Argiroffo C; Ruchonnet-Métrailler I

doi:10.4414/smw.2019.20081

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Journal article

A Swiss database and biobank to better understand and manage congenital lung anomalies.

Vidal I Division of Paediatric Surgery, Geneva University Hospital, University Centre of Paediatric Surgery of Western Switzerland, Geneva, Switzerland.
Wildhaber BE Division of Paediatric Surgery, Geneva University Hospital, University Centre of Paediatric Surgery of Western Switzerland, Geneva, Switzerland / Division of Paediatric Surgery, Lausanne University Hospital, University Centre of Paediatric Surgery of Western Switzerland, Lausanne, Switzerland.
Moehrlen U Division of Paediatric Pulmonology, Children's Hospital, St Gallen, Switzerland.
Regamey N Division of Paediatric Pulmonology, Children's Hospital of Lucerne, Switzerland.
Trachsel D Division of Intensive Care and Pulmonology, University of Basel Children's Hospital UKBB, Basel, Switzerland.
Cholewa D Department of Paediatric Surgery, Inselspital, University Hospital and University of Bern, Switzerland.
Barben J Department of Paediatric Surgery, Zurich Centre for Fetal Diagnosis and Therapy, University Children's Hospital Zurich, Zurich, Switzerland.
Barazzone-Argiroffo C Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland / Paediatric Pulmonology Unit, Department of Paediatrics, University Hospital Geneva, Switzerland.
Ruchonnet-Métrailler I Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Switzerland / Paediatric Pulmonology Unit, Department of Paediatrics, Geneva University Hospital, Switzerland.

2019-07-01

Published in:

Swiss medical weekly. - 2019

English Congenital lung anomalies are a group of rare malformations, often diagnosed during the prenatal period. Guidelines on how to manage these patients are currently under debate, especially with regard to prophylactic surgery in asymptomatic patients, or how to proceed with conservative follow-up. Currently, there is no clear consensus on management strategies. A Swiss congenital lung anomaly national database and biobank was created in 2016 to enable data recording and collection of surgical lung samples in order to help define the most appropriate management strategies. This national observational cohort study represents an important step towards a better understanding of the pathophysiology and clinical course of the diseases included under congenital lung anomalies, especially in the context of a small country like Switzerland.

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