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Journal article

Consortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure.

  • Hoogman M Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
  • van Rooij D Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • Klein M Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Boedhoe P Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Ilioska I Department of Cognitive Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Li T Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Patel Y Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
  • Postema MC Department of Language & Genetics, Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.
  • Zhang-James Y Department of Psychiatry and behavioral sciences, SUNY Upstate Medical University, Syracuse, New York, USA.
  • Anagnostou E Department of Pediatrics University of Toronto, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
  • Arango C Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Madrid, Spain.
  • Auzias G INT UMR 7289, Aix-Marseille Université, CNRS, France.
  • Banaschewski T Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
  • Bau CHD Department of Genetics, Institute of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • Behrmann M Department of Psychology and Neuroscience Institute, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
  • Bellgrove MA Turner Institute for Brain and Mental Health and School of Psychological Sciences, Monash University, Melbourne, Victoria, Australia.
  • Brandeis D Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Mannheim, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
  • Brem S Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
  • Busatto GF Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Calderoni S Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Pisa, Italy.
  • Calvo R IDIBAPS, Barcelona, Spain.
  • Castellanos FX Department of Child and Adolescent Psychiatry, Hassenfeld Children's Hospital at NYU Langone, New York, New York, USA.
  • Coghill D Department of Paediatrics and Psychiatry, University of Melbourne, Melbourne, Victoria, Australia.
  • Conzelmann A Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Psychiatry and Psychotherapy, Tübingen, Germany.
  • Daly E Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Deruelle C INT UMR 7289, Aix-Marseille Université, CNRS, France.
  • Dinstein I Department of Psychology, Ben Gurion University, Beer Sheva, Israel.
  • Durston S NICHE lab, Deptartment of Psychiatry, UMC Utrecht Brain Center, Utrecht, The Netherlands.
  • Ecker C Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Ehrlich S Division of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technischen Universität Dresden, Dresden, Germany.
  • Epstein JN Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Fair DA Department of Psychiatry, Oregon Health & Science University, Portland, Oregon, USA.
  • Fitzgerald J Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Freitag CM Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Autism Research and Intervention Center of Excellence, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
  • Frodl T Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Gallagher L Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Grevet EH Adulthood ADHD Outpatient Program (ProDAH), Clinical Research Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
  • Haavik J K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Biomedicine, University of Bergen, Bergen, Norway.
  • Hoekstra PJ Department of Child and Adolescent Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Janssen J Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Madrid, Spain.
  • Karkashadze G Scientific research institute of Pediatrics and child health of Central clinical Hospital RAoS, Moscow, Russia.
  • King JA Division of Psychological & Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technischen Universität Dresden, Dresden, Germany.
  • Konrad K Child Neuropsychology Section, University Hospital RWTH Aachen, Aachen, Germany.
  • Kuntsi J Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Lazaro L Department of Child and Adolescent Psychiatry and Psychology, Hospital Clínic, Barcelona, Spain.
  • Lerch JP Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department for Clinical Neurosciences, University of Oxford, UK.
  • Lesch KP Division of Molecular Psychiatry, Center of Mental Health, University of Würzburg, Würzburg, Germany.
  • Louza MR Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
  • Luna B Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Mattos P D'Or Institute for Research and Education, Rio de Janeiro, Brazil.
  • McGrath J Department of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.
  • Muratori F Department of Developmental Neuroscience, IRCCS Fondazione Stella Maris, Pisa, Italy.
  • Murphy C Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Nigg JT Department of Psychiatry, Oregon Health & Science University, Portland, Oregon, USA.
  • Oberwelland-Weiss E JARA Institute Molecular Neuroscience and Neuroimaging (INM-11), Institute for Neuroscience and Medicine, Research Center Jülich, Julich, Germany.
  • O'Gorman Tuura RL Center for MR Research, University Children's Hospital, Zurich, Switzerland.
  • O'Hearn K Department of physiology and pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
  • Oosterlaan J Clinical Neuropsychology Section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Parellada M Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, Madrid, Spain.
  • Pauli P Department of Biological Psychology, Clinical Psychology and Psychotherapy, Würzburg, Germany.
  • Plessen KJ Child and Adolescent Mental Health Centre, Copenhagen, Denmark.
  • Ramos-Quiroga JA Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain.
  • Reif A Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
  • Reneman L Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
  • Retico A National Institute for Nuclear Physics, Pisa, Italy.
  • Rosa PGP Laboratory of Psychiatric Neuroimaging (LIM-21), Departamento e Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Rubia K Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
  • Shaw P National Human Genome Research Institute, Bethesda, Maryland, USA.
  • Silk TJ Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
  • Tamm L Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Vilarroya O Department of Psychiatry and Forensic Medicine, Universitat Autonoma de Barcelona, Barcelona, Spain.
  • Walitza S Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland.
  • Jahanshad N Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA.
  • Faraone SV Department of Psychiatry and of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York, USA.
  • Francks C Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • van den Heuvel OA Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam UMC Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Paus T Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada.
  • Thompson PM Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Marina del Rey, California, USA.
  • Buitelaar JK Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands.
  • Franke B Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
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  • 2020-05-19
Published in:
  • Human brain mapping. - 2020
English Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA-ADHD and ENIGMA-ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA-ADHD and -ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case-control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case-control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow-up analyses continue that include more imaging modalities (diffusion MRI and resting-state functional MRI), collaborations with other large databases, and samples with dual diagnoses.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/74179
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