Journal article

Structural and functional diversity calls for a new classification of ABC transporters.

  • Thomas C Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Germany.
  • Aller SG Department of Pharmacology and Toxicology, University of Alabama at Birmingham, AL, USA.
  • Beis K Department of Life Sciences, Imperial College London, London South Kensington, UK.
  • Carpenter EP Structural Genomics Consortium, University of Oxford, UK.
  • Chang G Skaggs School of Pharmacy and Pharmaceutical Sciences and Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
  • Chen L State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing, China.
  • Dassa E Institut Pasteur, Paris Cedex 15, France.
  • Dean M Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Gaithersburg, MD, USA.
  • Duong Van Hoa F Department of Biochemistry and Molecular Biology, Faculty of Medicine, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
  • Ekiert D Department of Cell Biology and Department of Microbiology, New York University School of Medicine, NY, USA.
  • Ford R Faculty of Biology, Medicine and Health, The University of Manchester, UK.
  • Gaudet R Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.
  • Gong X Department of Biology, Southern University of Science and Technology, Shenzhen, China.
  • Holland IB Institute for Integrative Biology of the Cell (I2BC), Université Paris-Sud, Orsay, France.
  • Huang Y National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
  • Kahne DK Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
  • Kato H Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Japan.
  • Koronakis V Department of Pathology, University of Cambridge, UK.
  • Koth CM Structural Biology, Genentech Inc., South San Francisco, CA, USA.
  • Lee Y Division of Integrative Bioscience and Biotechnology, POSTECH, Pohang, Korea.
  • Lewinson O Department of Biochemistry, The Bruce and Ruth Rappaport Faculty of Medicine, The Technion-Israel Institute of Technology, Haifa, Israel.
  • Lill R Institut für Zytobiologie, Philipps-Universität Marburg, Germany.
  • Martinoia E Department of Plant and Microbial Biology, University Zurich, Switzerland.
  • Murakami S Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan.
  • Pinkett HW Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
  • Poolman B Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.
  • Rosenbaum D Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Sarkadi B Institute of Enzymology, Research Center for Natural Sciences (RCNS), Budapest, Hungary.
  • Schmitt L Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
  • Schneider E Department of Biology/Microbial Physiology, Humboldt-University of Berlin, Germany.
  • Shi Y Institute of Biology, Westlake Institute for Advanced Study, School of Life Sciences, Westlake University, Hangzhou, China.
  • Shyng SL Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, OR, USA.
  • Slotboom DJ Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands.
  • Tajkhorshid E Department of Biochemistry, Center for Biophysics and Quantitative Biology, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA.
  • Tieleman DP Department of Biological Sciences and Centre for Molecular Simulation, University of Calgary, AB, Canada.
  • Ueda K Institute for Integrated Cell-Material Sciences (WPI-iCeMS), KUIAS, Kyoto University, Japan.
  • Váradi A Institute of Enzymology, Research Center for Natural Sciences (RCNS), Budapest, Hungary.
  • Wen PC Department of Biochemistry, Center for Biophysics and Quantitative Biology, NIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, USA.
  • Yan N Department of Molecular Biology, Princeton University, NJ, USA.
  • Zhang P National Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Zheng H Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Zimmer J Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.
  • Tampé R Institute of Biochemistry, Biocenter, Goethe University Frankfurt, Germany.
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  • 2020-09-26
Published in:
  • FEBS letters. - 2020
English Members of the ATP-binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous ATP-binding cassette in the nucleotide-binding domains (NBDs) is highly conserved, their transmembrane domains (TMDs) forming the translocation pathway exhibit distinct folds and topologies, suggesting that during evolution the ancient motor domains were combined with different transmembrane mechanical systems to orchestrate a variety of cellular processes. In recent years, it has become increasingly evident that the distinct TMD folds are best suited to categorize the multitude of ABC transporters. We therefore propose a new ABC transporter classification that is based on structural homology in the TMDs.
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  • English
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hybrid
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https://sonar.ch/global/documents/74232
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