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Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones.

  • Hsieh SY Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich , 8093 Zürich, Switzerland.
  • Bode JW Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich , 8093 Zürich, Switzerland.
  • 2016-04-22
Published in:
  • Organic letters. - 2016
Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry
English Silicon amine protocol (SLAP) reagents for photocatalytic cross-coupling with aldehydes and ketones to form N-unprotected piperazines have been developed. This blue light promoted process tolerates a wide range of heteroaromatic, aromatic, and aliphatic aldehydes and structurally and stereochemically complex SLAP reagents. It provides a tin-free alternative to SnAP (tin amine protocol) reagents for the synthesis of substituted piperazines.
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  • English
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green
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https://sonar.ch/global/documents/76175
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