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Structure and Function of the Mitochondrial Ribosome.
Journal article

Structure and Function of the Mitochondrial Ribosome.

  • Greber BJ Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, CH-8093 Zurich, Switzerland; email: ban@mol.biol.ethz.ch.
  • Ban N Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zurich, CH-8093 Zurich, Switzerland; email: ban@mol.biol.ethz.ch.
  • 2016-03-30
Published in:
  • Annual review of biochemistry. - 2016
28S mitoribosomal subunit
39S mitoribosomal subunit
antibiotics
cryo-electron microscopy
mitochondrial translation
ribosome evolution
Animals
Anti-Bacterial Agents
Biological Evolution
Carboxylic Ester Hydrolases
DNA, Mitochondrial
Mammals
Mitochondria
Mitochondrial Membranes
Mitochondrial Proteins
Mitochondrial Ribosomes
Models, Molecular
Protein Biosynthesis
RNA, Messenger
RNA, Transfer
Ribosome Subunits
Saccharomyces cerevisiae
English Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the organelles responsible for energy conversion and adenosine triphosphate production in eukaryotic cells. Throughout evolution, mitoribosomes have become functionally specialized for synthesizing mitochondrial membrane proteins, and this has been accompanied by large changes to their structure and composition. We review recent high-resolution structural data that have provided unprecedented insight into the structure and function of mitoribosomes in mammals and fungi.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/76271
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