Journal article

Genetic studies of body mass index yield new insights for obesity biology.

  • Locke AE Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Kahali B Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Berndt SI Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Justice AE Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Pers TH Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Day FR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Powell C Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Vedantam S Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Buchkovich ML Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Yang J Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  • Croteau-Chonka DC Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Esko T Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Fall T Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Ferreira T Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Gustafsson S Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
  • Kutalik Z Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne 1010, Switzerland.
  • Luan J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Mägi R Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Randall JC Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Winkler TW Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
  • Wood AR Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
  • Workalemahu T Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Faul JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA.
  • Smith JA Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Zhao JH MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Zhao W Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Chen J Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Fehrmann R Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Hedman ÅK Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
  • Karjalainen J Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Schmidt EM Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Absher D HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
  • Amin N Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
  • Anderson D Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Western Australia 6008, Australia.
  • Beekman M Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
  • Bolton JL Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
  • Bragg-Gresham JL Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Buyske S Department of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey 08854, USA.
  • Demirkan A Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
  • Deng G Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  • Ehret GB Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
  • Feenstra B Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark.
  • Feitosa MF Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Fischer K Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Goel A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Gong J Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Jackson AU Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Kanoni S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
  • Kleber ME Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
  • Kristiansson K National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Lim U Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
  • Lotay V The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Mangino M Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
  • Leach IM Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
  • Medina-Gomez C Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
  • Medland SE QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Nalls MA Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Palmer CD Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Pasko D Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
  • Pechlivanis S Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.
  • Peters MJ Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
  • Prokopenko I Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Shungin D Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.
  • Stančáková A University of Eastern Finland, FI-70210 Kuopio, Finland.
  • Strawbridge RJ Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
  • Sung YJ Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Tanaka T Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
  • Teumer A Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
  • Trompet S Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
  • van der Laan SW Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • van Setten J Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Van Vliet-Ostaptchouk JV Department of Endocrinology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
  • Wang Z Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Yengo L CNRS UMR 8199, F-59019 Lille, France.
  • Zhang W Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  • Isaacs A Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
  • Albrecht E Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • Ärnlöv J Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
  • Arscott GM PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.
  • Attwood AP Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.
  • Bandinelli S Geriatric Unit, Azienda Sanitaria Firenze (ASF), 50125 Florence, Italy.
  • Barrett A Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
  • Bas IN USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
  • Bellis C Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78227, USA.
  • Bennett AJ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
  • Berne C Department of Medical Sciences, Endocrinology, Diabetes and Metabolism, Uppsala University, Uppsala 75185, Sweden.
  • Blagieva R Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
  • Blüher M Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
  • Böhringer S Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
  • Bonnycastle LL Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
  • Böttcher Y Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
  • Boyd HA Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark.
  • Bruinenberg M LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Caspersen IH Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
  • Chen YI Department of Pediatrics, University of California Los Angeles, Torrance, California 90502, USA.
  • Clarke R Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.
  • Daw EW Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • de Craen AJM Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
  • Delgado G Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
  • Dimitriou M Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece.
  • Doney ASF Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
  • Eklund N National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Estrada K Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
  • Eury E CNRS UMR 8199, F-59019 Lille, France.
  • Folkersen L Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
  • Fraser RM Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
  • Garcia ME Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
  • Geller F Department of Epidemiology Research, Statens Serum Institut, Copenhagen DK-2300, Denmark.
  • Giedraitis V Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala 75185, Sweden.
  • Gigante B Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
  • Go AS Kaiser Permanente, Division of Research, Oakland, California 94612, USA.
  • Golay A Service of Therapeutic Education for Diabetes, Obesity and Chronic Diseases, Geneva University Hospital, Geneva CH-1211, Switzerland.
  • Goodall AH Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
  • Gordon SD QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Gorski M Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
  • Grabe HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, D-17475 Greifswald, Germany.
  • Grallert H Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • Grammer TB Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
  • Gräßler J Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
  • Grönberg H Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Groves CJ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
  • Gusto G Institut inter Régional pour la Santé, Synergies, F-37520 La Riche, France.
  • Haessler J Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Hall P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Haller T Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Hallmans G Department of Public Health and Clinical Medicine, Unit of Nutritional Research, Umeå University, Umeå 90187, Sweden.
  • Hartman CA Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.
  • Hassinen M Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
  • Hayward C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
  • Heard-Costa NL National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  • Helmer Q Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
  • Hengstenberg C Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.
  • Holmen O Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway.
  • Hottenga JJ Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.
  • James AL Department of Pulmonary Physiology and Sleep Medicine, Nedlands, Western Australia 6009, Australia.
  • Jeff JM The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Johansson Å Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden.
  • Jolley J Department of Haematology, University of Cambridge, Cambridge CB2 0PT, UK.
  • Juliusdottir T Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Kinnunen L National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Koenig W Department of Internal Medicine II, Ulm University Medical Centre, D-89081 Ulm, Germany.
  • Koskenvuo M Hjelt Institute Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland.
  • Kratzer W Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
  • Laitinen J Finnish Institute of Occupational Health, FI-90100 Oulu, Finland.
  • Lamina C Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria.
  • Leander K Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
  • Lee NR USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City 6000, Philippines.
  • Lichtner P Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • Lind L Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
  • Lindström J National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Lo KS Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
  • Lobbens S CNRS UMR 8199, F-59019 Lille, France.
  • Lorbeer R Institute for Community Medicine, University Medicine Greifswald, D-17475 Greifswald, Germany.
  • Lu Y The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Mach F Cardiology, Department of Specialties of Internal Medicine, Geneva University Hospital, Geneva 1211, Switzerland.
  • Magnusson PKE Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Mahajan A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • McArdle WL School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • McLachlan S Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
  • Menni C Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
  • Merger S Division of Endocrinology, Diabetes and Metabolism, Ulm University Medical Centre, D-89081 Ulm, Germany.
  • Mihailov E Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Milani L Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Moayyeri A Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
  • Monda KL Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • Morken MA Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
  • Mulas A Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy.
  • Müller G Center for Evidence-based Healthcare, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
  • Müller-Nurasyid M Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • Musk AW Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia 6009, Australia.
  • Nagaraja R Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA.
  • Nöthen MM Department of Genomics, Life & Brain Center, University of Bonn, 53127 Bonn, Germany.
  • Nolte IM Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Pilz S Department of Epidemiology and Biostatistics, Institute for Research in Extramural Medicine, Institute for Health and Care Research, VU University Medical Center, 1081BT Amsterdam, The Netherlands.
  • Rayner NW Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Renstrom F Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hosptial, Malmö 205 02, Sweden.
  • Rettig R Institute of Physiology, University Medicine Greifswald, D-17495 Karlsburg, Germany.
  • Ried JS Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • Ripke S Analytic and Translational Genetics Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
  • Robertson NR Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Rose LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
  • Sanna S Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cagliari, Sardinia 09042, Italy.
  • Scharnagl H Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.
  • Scholtens S LifeLines Cohort Study, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Schumacher FR Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Scott WR Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  • Seufferlein T Department of Internal Medicine I, Ulm University Medical Centre, D-89081 Ulm, Germany.
  • Shi J National Cancer Institute, Bethesda, Maryland 20892, USA.
  • Smith AV Icelandic Heart Association, Kopavogur 201, Iceland.
  • Smolonska J Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Stanton AV Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephen's Green, Dublin 2, Ireland.
  • Steinthorsdottir V deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
  • Stirrups K Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Stringham HM Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Sundström J Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala 75185, Sweden.
  • Swertz MA Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Swift AJ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, Maryland 20892, USA.
  • Syvänen AC Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
  • Tan ST Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  • Tayo BO Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA.
  • Thorand B German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany.
  • Thorleifsson G deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
  • Tyrer JP Department of Oncology, University of Cambridge, Cambridge CB2 0QQ, UK.
  • Uh HW Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
  • Vandenput L Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
  • Verhulst FC Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Centre, 3000 CB Rotterdam, The Netherlands.
  • Vermeulen SH Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
  • Verweij N Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
  • Vonk JM Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Waite LL HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, USA.
  • Warren HR Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
  • Waterworth D Genetics, GlaxoSmithKline, King of Prussia, Pennsylvania 19406, USA.
  • Weedon MN Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
  • Wilkens LR Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
  • Willenborg C German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.
  • Wilsgaard T Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
  • Wojczynski MK Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Wong A MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
  • Wright AF MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.
  • Zhang Q Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Brennan EP Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Korea.
  • Choi M Lady Davis Institute, Departments of Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal, Québec H3T1E2, Canada.
  • Dastani Z Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Drong AW Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
  • Eriksson P Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm 17176, Sweden.
  • Franco-Cereceda A Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
  • Gådin JR Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA.
  • Gharavi AG Biosciences Research Division, Department of Primary Industries, Victoria 3083, Australia.
  • Goddard ME Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
  • Handsaker RE Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Huang J Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford OX3 7LJ, UK.
  • Karpe F Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
  • Kathiresan S Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Keildson S Department of Medicine, Columbia University College of Physicians and Surgeons, New York 10032, USA.
  • Kiryluk K Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
  • Kubo M Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Chungbuk 363-951, Republic of Korea.
  • Lee JY Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Liang L Department of Genetics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, New Haven, Connecticut 06520, USA.
  • Lifton RP Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Ma B Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
  • McCarroll SA Nephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, County Down BT9 7AB, UK.
  • McKnight AJ School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
  • Min JL National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Moffatt MF QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Montgomery GW National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  • Murabito JM Department of Statistics, University of Oxford, 1 South Parks Road, Oxford OX1 3TG, UK.
  • Nicholson G QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Nyholt DR Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
  • Okada Y Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Perry JRB Genome Institute of Singapore, Agency for Science, Technology and Research, 138672 Singapore.
  • Dorajoo R Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Reinmaa E Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Salem RM Department of Biomedical Engineering and Computational Science, Aalto University School of Science, Helsinki FI-00076, Finland.
  • Sandholm N MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Scott RA Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
  • Stolk L Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama 230-0045, Japan.
  • Takahashi A Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 113-8510 Tokyo, Japan.
  • Tanaka T Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
  • van 't Hooft FM Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  • Vinkhuyzen AAE Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Westra HJ Division of Epidemiology, Department of Medicine; Vanderbilt Epidemiology Center; and Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37075, USA.
  • Zheng W Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Zondervan KT Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Heath AC Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.
  • Arveiler D National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  • Bakker SJL Department of Health Sciences, University of Milano, I 20142, Italy.
  • Beilby J Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
  • Bergman RN Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm 17177, Sweden.
  • Blangero J Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Bovet P Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
  • Campbell H Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, 45147 Essen, Germany.
  • Caulfield MJ German Center for Cardiovascular Research, partner site Hamburg/Lubeck/Kiel, 23562 Lubeck, Germany.
  • Cesana G National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Chakravarti A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Chasman DI Department of Internal Medicine B, University Medicine Greifswald, D-17475 Greifswald, Germany.
  • Chines PS Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy.
  • Collins FS Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, 31400 Toulouse, France.
  • Crawford DC Robertson Center for Biostatistics, University of Glasgow, Glasgow G12 8QQ, UK.
  • Cupples LA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Cusi D UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
  • Danesh J Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
  • de Faire U Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands.
  • den Ruijter HM NorthShore University HealthSystem, Evanston, IL 60201, University of Chicago, Chicago, Illinois, USA.
  • Dominiczak AF Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • Erbel R The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Erdmann J Icelandic Heart Association, Kopavogur 201, Iceland.
  • Eriksson JG Uppsala University, Department of Immunology, Genetics, Pathology, SciLifeLab, Rudbeck Laboratory, SE-751 85 Uppsala, Sweden.
  • Farrall M Leeds MRC Medical Bioinformatics Centre, University of Leeds, Leeds LS2 9LU, UK.
  • Felix SB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
  • Ferrannini E Institute of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK.
  • Ferrières J Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany).
  • Ford I Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Forouhi NG Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
  • Forrester T Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
  • Franco OH Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
  • Gansevoort RT Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
  • Gejman PV Centre for Cardiovascular Genetics, Institute Cardiovascular Sciences, University College London, London WC1E 6JJ, UK.
  • Gieger C Cardiovascular Genetics Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah 84108, USA.
  • Gottesman O Sansom Institute for Health Research, University of South Australia, Adelaide 5000, South Australia, Australia.
  • Gudnason V Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • Gyllensten U Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Hall AS Department of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
  • Harris TB Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.
  • Hattersley AT Department of Biology, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
  • Hicks AA National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Hindorff LA Department of Cardiology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
  • Hingorani AD National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Hofman A National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Homuth G Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, The Netherlands.
  • Hovingh GK Institute of Health Sciences, University of Oulu, FI-90014 Oulu, Finland.
  • Humphries SE Department for Health Evidence, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands.
  • Hunt SC National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Hyppönen E Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  • Illig T Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Jacobs KB Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
  • Jarvelin MR Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Jöckel KH Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
  • Johansen B Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
  • Jousilahti P Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
  • Jukema JW MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Jula AM Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii 96813, USA.
  • Kaprio J Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine University of Tampere, FI-33520 Tampere, Finland.
  • Kastelein JJP Steno Diabetes Center A/S, Gentofte DK-2820, Denmark.
  • Keinanen-Kiukaanniemi SM National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Kiemeney LA Institut Universitaire de Cardiologie et de Pneumologie de Québec, Faculty of Medicine, Laval University, Quebec, QC G1V 0A6, Canada.
  • Knekt P Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA.
  • Kooner JS UWI Solutions for Developing Countries, The University of the West Indies, Mona, Kingston 7, Jamaica.
  • Kooperberg C Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.
  • Kovacs P Department of Surgery, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Kraja AT Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
  • Kumari M Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Kuusisto J Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA.
  • Lakka TA Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Langenberg C Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg 413 45, Sweden.
  • Marchand LL Department of Psychiatry, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.
  • Lehtimäki T MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Lyssenko V Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Männistö S Experimental Cardiology Laboratory, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Marette A Illumina, Inc, Little Chesterford, Cambridge CB10 1XL, UK.
  • Matise TC Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • McKenzie CA University of Groningen, University Medical Center Groningen, Department of Pulmonary Medicine and Tuberculosis, Groningen, The Netherlands.
  • McKnight B Center for Biomedicine, European Academy Bozen, Bolzano (EURAC), Bolzano 39100, Italy (affiliated institute of the University of Lübeck, D-23562 Lübeck, Germany).
  • Moll FL Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
  • Morris AD Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Morris AP Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, FI-20521 Turku, Finland.
  • Murray JC Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
  • Nelis M Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Ohlsson C Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Oldehinkel AJ Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
  • Ong KK Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
  • Madden PAF Center for Systems Genomics, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
  • Pasterkamp G Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
  • Peden JF National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Peters A Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
  • Postma DS South Carelia Central Hospital, 53130 Lappeenranta, Finland.
  • Pramstaller PP Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
  • Price JF Deutsches Forschungszentrum für Herz-Kreislauferkrankungen (DZHK) (German Research Centre for Cardiovascular Research), Munich Heart Alliance, D-80636 Munich, Germany.
  • Qi L Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
  • Raitakari OT International Centre for Circulatory Health, Imperial College London, London W2 1PG, UK.
  • Rankinen T Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
  • Rao DC Helsinki University Central Hospital Heart and Lung Center, Department of Medicine, Helsinki University Central Hospital, FI-00290 Helsinki, Finland.
  • Rice TK Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Ridker PM Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, D-85764 Neuherberg, Germany.
  • Rioux JD Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
  • Ritchie MD Sorbonne Universités, UPMC Univ Paris 06, UMR S 1166, F-75013 Paris, France.
  • Rudan I Department of Kinesiology, Laval University, Quebec QC G1V 0A6, Canada.
  • Salomaa V Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano & Centro Cardiologico Monzino, Instituto di Ricovero e Cura a Carattere Scientifico, Milan 20133, Italy.
  • Samani NJ National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Saramies J Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.
  • Sarzynski MA Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, D-17475 Greifswald, Germany.
  • Schunkert H Department of Internal Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne 1011, Switzerland.
  • Schwarz PEH Biological Psychology, VU University Amsterdam, 1081BT Amsterdam, The Netherlands.
  • Sever P Department of Epidemiology, Erasmus MC University Medical Center, 3015GE Rotterdam, The Netherlands.
  • Shuldiner AR Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
  • Sinisalo J Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Stolk RP Institut Pasteur de Lille; INSERM, U744; Université de Lille 2; F-59000 Lille, France.
  • Strauch K Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
  • Tönjes A Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
  • Trégouët DA Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1010 Lausanne, Switzerland.
  • Tremblay A Lee Kong Chian School of Medicine, Imperial College London and Nanyang Technological University, Singapore, 637553 Singapore, Singapore.
  • Tremoli E Health Science Center at Houston, University of Texas, Houston, Texas 77030, USA.
  • Virtamo J Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, D-01307 Dresden, Germany.
  • Vohl MC The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
  • Völker U Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
  • Waeber G CNRS UMR 8199, F-59019 Lille, France.
  • Willemsen G Ealing Hospital NHS Trust, Middlesex UB1 3HW, UK.
  • Witteman JC Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Zillikens MC Department of Public Health Sciences, Stritch School of Medicine, Loyola University of Chicago, Maywood, Illinois 61053, USA.
  • Adair LS Department of Medical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Amouyel P Department of Dietetics-Nutrition, Harokopio University, 17671 Athens, Greece.
  • Asselbergs FW Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21225, USA.
  • Assimes TL Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
  • Bochud M Department of Genomics of Common Disease, School of Public Health, Imperial College London, Hammersmith Hospital, London W12 0NN, UK.
  • Boehm BO Institute for Molecular Medicine, University of Helsinki, FI-00014 Helsinki, Finland.
  • Boerwinkle E Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
  • Bornstein SR Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
  • Bottinger EP PathWest Laboratory Medicine of Western Australia, Nedlands, Western Australia 6009, Australia.
  • Bouchard C Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Cauchi S Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim 7489, Norway.
  • Chambers JC Albert Einstein College of Medicine, Department of Epidemiology and Population Health, Belfer 1306, New York 10461, USA.
  • Chanock SJ Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
  • Cooper RS MRC Unit for Lifelong Health and Ageing at University College London, London WC1B 5JU, UK.
  • de Bakker PIW Department of Medicine, Kuopio University Hospital and University of Eastern Finland, FI-70210 Kuopio, Finland.
  • Dedoussis G Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
  • Ferrucci L QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.
  • Franks PW Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, D-68187 Mannheim, Germany.
  • Froguel P Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
  • Groop LC Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Haiman CA Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.
  • Hamsten A Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
  • Hui J Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, 9037 Tromsø, Norway.
  • Hunter DJ Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
  • Hveem K Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
  • Kaplan RC Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Kivimaki M Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
  • Kuh D Institute of Nutrition and Functional Foods, Laval University, Quebec, QC G1V 0A6, Canada.
  • Laakso M Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
  • Liu Y Population, Policy, and Practice, University College London Institute of Child Health, London WC1N 1EH, UK.
  • Martin NG Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
  • März W Kuopio Research Institute of Exercise Medicine, 70100 Kuopio, Finland.
  • Melbye M Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
  • Metspalu A Finnish Diabetes Association, Kirjoniementie 15, FI-33680 Tampere, Finland.
  • Moebus S Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
  • Munroe PB BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
  • Njølstad I Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York 10580, USA.
  • Oostra BA Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland 21224, USA.
  • Palmer CNA Netherlands Consortium for Healthy Aging (NCHA), Leiden University Medical Center, Leiden 2300 RC, The Netherlands.
  • Pedersen NL Department of Epidemiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Perola M Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
  • Pérusse L deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
  • Peters U Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, D-04103 Leipzig, Germany.
  • Power C National Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  • Quertermous T Netherlands Consortium for Healthy Aging (NCHA), 3015GE Rotterdam, The Netherlands.
  • Rauramaa R Department of Public Health and Clinical Nutrition, University of Eastern Finland, Finland.
  • Rivadeneira F Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Saaristo TE Institute of Cellular Medicine, Newcastle University, Newcastle NE1 7RU, UK.
  • Saleheen D DZHK (Deutsches Zentrum für Herz-Kreislaufforschung - German Centre for Cardiovascular Research), partner site Greifswald, D-17475 Greifswald, Germany.
  • Sattar N MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Schadt EE Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Schlessinger D Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA.
  • Slagboom PE Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Ludwig-Maximilians-Universität, D-85764 Munich, Germany.
  • Snieder H Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
  • Spector TD Department of Pulmonology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.
  • Thorsteinsdottir U Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA.
  • Stumvoll M Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Tuomilehto J National Heart, Lung, and Blood Institute, the Framingham Heart Study, Framingham, Massachusetts 01702, USA.
  • Uitterlinden AG Department of Genetic Epidemiology, Institute of Epidemiology and Preventive Medicine, University of Regensburg, D-93053 Regensburg, Germany.
  • Uusitupa M Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
  • van der Harst P Division of Population Health Sciences & Education, St George's, University of London, London SW17 0RE, UK.
  • Walker M deCODE Genetics, Amgen Inc., Reykjavik 101, Iceland.
  • Wallaschofski H Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, 3015 GE Rotterdam, The Netherlands.
  • Wareham NJ Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Watkins H Department of Genetics, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
  • Weir DR Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
  • Wichmann HE Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
  • Wilson JF Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia.
  • Zanen P Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen, 45147 Essen, Germany.
  • Borecki IB Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Deloukas P Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • Fox CS Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
  • Heid IM Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts 02142, USA.
  • O'Connell JR Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
  • Strachan DP Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.
  • Stefansson K Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
  • van Duijn CM Science for Life Laboratory, Uppsala University, Uppsala 75185, Sweden.
  • Abecasis GR Divisions of Endocrinology and Genetics and Center for Basic and Translational Obesity Research, Boston Children's Hospital, Boston, Massachusetts 02115, USA.
  • Franke L MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
  • Frayling TM Department of Internal Medicine, Division of Gastroenterology, and Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
  • McCarthy MI
  • Visscher PM
  • Scherag A
  • Willer CJ
  • Boehnke M
  • Mohlke KL
  • Lindgren CM
  • Beckmann JS
  • Barroso I
  • North KE
  • Ingelsson E
  • Hirschhorn JN
  • Loos RJF
  • Speliotes EK
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  • 2015-02-13
Published in:
  • Nature. - 2015
English Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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  • English
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https://sonar.ch/global/documents/76716
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