Journal article

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

  • Okbay A Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
  • Baselmans BM Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
  • De Neve JE Saïd Business School, University of Oxford, Oxford, UK.
  • Turley P Department of Economics, Harvard University, Cambridge, Massachusetts, USA.
  • Nivard MG Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
  • Fontana MA Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
  • Meddens SF Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
  • Linnér RK Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
  • Rietveld CA Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
  • Derringer J Department of Psychology, University of Illinois, Champaign, Illinois, USA.
  • Gratten J Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Lee JJ Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
  • Liu JZ New York Genome Center, New York, New York, USA.
  • de Vlaming R Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
  • Ahluwalia TS COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
  • Buchwald J Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Cavadino A Centre for Environmental and Preventive Medicine, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
  • Frazier-Wood AC USDA-ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.
  • Furlotte NA 23andMe, Inc., Mountain View, California, USA.
  • Garfield V Department of Epidemiology and Public Health, University College London, London, UK.
  • Geisel MH Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany.
  • Gonzalez JR Centre for Research in Environmental Epidemiology, Institute for Global Health, Barcelona, Spain.
  • Haitjema S Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Karlsson R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • van der Laan SW Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Ladwig KH Department of Psychosomatic Medicine and Psychotherapy, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
  • Lahti J Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
  • van der Lee SJ Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Lind PA Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Liu T Max Planck Institute for Human Development, Berlin, Germany.
  • Matteson L Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
  • Mihailov E Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Miller MB Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
  • Minica CC Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
  • Nolte IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Mook-Kanamori D Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • van der Most PJ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Oldmeadow C Public Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales, Australia.
  • Qian Y Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.
  • Raitakari O Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
  • Rawal R Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Realo A Department of Psychology, University of Tartu, Tartu, Estonia.
  • Rueedi R Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.
  • Schmidt B Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany.
  • Smith AV Icelandic Heart Association, Kopavogur, Iceland.
  • Stergiakouli E MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Tanaka T National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
  • Taylor K Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA, Torrence, California, USA.
  • Thorleifsson G Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Wedenoja J Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
  • Wellmann J Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Westra HJ Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Willems SM Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Zhao W Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Amin N Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA.
  • Bakshi A RAND Corporation, Santa Monica, California, USA.
  • Bergmann S Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Bjornsdottir G Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Boyle PA MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Cherney S Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.
  • Cox SR Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Davies G German Socio-Economic Panel Study, DIW Berlin, Berlin, Germany.
  • Davis OS Institute of Epidemiology II, Mental Health Research Unit, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Ding J Farr Institute of Health Informatics, University College London, London, UK.
  • Direk N Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
  • Eibich P National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
  • Emeny RT Institute of Human Genetics, University of Bonn, Bonn, Germany.
  • Fatemifar G Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
  • Faul JD Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Ferrucci L Laboratory of Epidemiology, Demography, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
  • Forstner AJ Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Gieger C Public Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales, Australia.
  • Gupta R Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
  • Harris TB Program in Translational NeuroPsychiatric Genomics, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA.
  • Harris JM Department of Genomics of Common Disease, Imperial College London, London, UK.
  • Holliday EG Department of Pediatrics, University of Helsinki, Helsinki, Finland.
  • Hottenga JJ Center for Life Course Health Research, University of Oulu and Oulu University Hospital, Oulu, Finland.
  • De Jager PL Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
  • Kaakinen MA Institute for Social and Economic Research, University of Essex, Wivenhoe Park, UK.
  • Kajantie E Neuroepidemiology Section, National Institute on Aging, US National Institutes of Health, Bethesda, Maryland, USA.
  • Karhunen V Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Kolcic I Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Kumari M Department of Neurology, General Hospital and Medical University Graz, Graz, Austria.
  • Launer LJ Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Franke L Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Li-Gao R Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Liewald DC Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Koini M MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Loukola A Department of Psychology, University of Edinburgh, Edinburgh, UK.
  • Marques-Vidal P Department of Neurology, General Hospital and Medical University Graz, Graz, Austria.
  • Montgomery GW Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
  • Mosing MA Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Paternoster L Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
  • Pattie A Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Petrovic KE Faculty of Health and Medicine, University of Newcastle, Newcastle, New South Wales, Australia.
  • Pulkki-Råback L Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Quaye L National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
  • Räikkönen K Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Rudan I Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Scott RJ Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
  • Smith JA Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
  • Sutin AR Public Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales, Australia.
  • Trzaskowski M Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
  • Vinkhuyzen AE Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
  • Yu L Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institute of Neurogenetics and Institute of Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.
  • Zabaneh D Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
  • Attia JR Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Bennett DA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Berger K Istituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, Cittadella Universitarià di Monserrato, Monserrato, Italy.
  • Bertram L Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
  • Boomsma DI Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Snieder H Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.
  • Chang SC Department of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Cucca F Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
  • Deary IJ Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
  • van Duijn CM Icelandic Heart Association, Kopavogur, Iceland.
  • Eriksson JG Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  • Bültmann U Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • de Geus EJ MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Groenen PJ MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
  • Gudnason V Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
  • Hansen T 23andMe, Inc., Mountain View, California, USA.
  • Hartman CA South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
  • Haworth CM Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
  • Hayward C Department of Genomics of Common Disease, Imperial College London, London, UK.
  • Heath AC Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, Essen, Germany.
  • Hinds DA Department of Public Health, University of Helsinki, Helsinki, Finland.
  • Hyppönen E Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
  • Iacono WG Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
  • Järvelin MR Department of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Jöckel KH Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
  • Kaprio J Fimlab Laboratories, Tampere, Finland.
  • Kardia SL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Keltikangas-Järvinen L Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Kraft P Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
  • Kubzansky LD Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Lehtimäki T Department of Sociology, University of Oxford, Oxford, UK.
  • Magnusson PK Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Martin NG Econometric Institute, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
  • McGue M Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Metspalu A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
  • Mills M Social, Genetic and Developmental Psychiatry Centre, King's College London, De Crespigny Park, UK.
  • de Mutsert R Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
  • Oldehinkel AJ South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
  • Pasterkamp G Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.
  • Pedersen NL Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
  • Plomin R Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands.
  • Polasek O Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA.
  • Power C Department of Neurology, General Hospital and Medical University Graz, Graz, Austria.
  • Rich SS Department of Economics, Oulu Business School, Oulu, Finland.
  • Rosendaal FR Department of Neurology, General Hospital and Medical University Graz, Graz, Austria.
  • den Ruijter HM Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
  • Schlessinger D Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark.
  • Schmidt H Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Svento R Department of Epidemiology and Public Health, University College London, London, UK.
  • Schmidt R National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.
  • Alizadeh BZ Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
  • Sørensen TI MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Spector TD Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Starr JM Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Stefansson K Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
  • Steptoe A Max Planck Institute for Human Development, Berlin, Germany.
  • Terracciano A Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
  • Thorsteinsdottir U Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
  • Thurik AR Department of Sociology, Princeton University, Princeton, New Jersey, USA.
  • Timpson NJ MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Tiemeier H Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Uitterlinden AG Department of Economics, Stockholm School of Economics, Stockholm, Sweden.
  • Vollenweider P Department of Economics, Harvard University, Cambridge, Massachusetts, USA.
  • Wagner GG Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Weir DR Department of Bioethics, Clarkson University, Schenectady, New York, USA.
  • Yang J New York Genome Center, New York, New York, USA.
  • Conley DC Estonian Genome Center, University of Tartu, Tartu, Estonia.
  • Smith GD Department of Psychology, University of Minnesota Twin Cities, Minneapolis, Minnesota, USA.
  • Hofman A Department of Economics, Harvard University, Cambridge, Massachusetts, USA.
  • Johannesson M Erasmus University Rotterdam Institute for Behavior and Biology, Rotterdam, the Netherlands.
  • Laibson DI Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
  • Medland SE Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
  • Meyer MN Department of Economics, New York University, New York, New York, USA.
  • Pickrell JK
  • Esko T
  • Krueger RF
  • Beauchamp JP
  • Koellinger PD
  • Benjamin DJ
  • Bartels M
  • Cesarini D
Show more…
  • 2016-04-19
Published in:
  • Nature genetics. - 2016
English Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
Language
  • English
Open access status
green
Identifiers
Persistent URL
https://sonar.ch/global/documents/76822
Statistics

Document views: 84 File downloads:
  • Full-text: 0