Rare and low-frequency coding variants alter human adult height.
-
Marouli E
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
-
Graff M
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Medina-Gomez C
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
-
Lo KS
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
-
Wood AR
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
-
Kjaer TR
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark.
-
Fine RS
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
-
Lu Y
Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
-
Schurmann C
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
-
Highland HM
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Rüeger S
Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.
-
Thorleifsson G
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.
-
Justice AE
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Lamparter D
Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
-
Stirrups KE
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
-
Turcot V
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
-
Young KL
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Winkler TW
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.
-
Esko T
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
-
Karaderi T
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
-
Locke AE
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Masca NG
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
-
Ng MC
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
-
Mudgal P
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
-
Rivas MA
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
-
Vedantam S
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
-
Mahajan A
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
-
Guo X
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
-
Abecasis G
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Aben KK
Netherlands Comprehensive Cancer Organisation, Utrecht, 3501 DB, The Netherlands.
-
Adair LS
Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
-
Alam DS
Centre for Control of Chronic Diseases (CCCD), Dhaka, 1212, Bangladesh.
-
Albrecht E
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
-
Allin KH
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
Allison M
Department of Family Medicine &Public Health, University of California, San Diego, La Jolla, California 92093, USA.
-
Amouyel P
INSERM U1167, Lille, F-59019, France.
-
Appel EV
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
Arveiler D
Department of Epidemiology and Public Health, University of Strasbourg, Strasbourg, F-67085, France.
-
Asselbergs FW
Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
-
Auer PL
Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, USA.
-
Balkau B
INSERM U1018, Centre de recherche en Épidemiologie et Sante des Populations (CESP), Villejuif, France.
-
Banas B
Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany.
-
Bang LE
Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
-
Benn M
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
-
Bergmann S
Swiss Institute of Bioinformatics, Lausanne, 1015, Switzerland.
-
Bielak LF
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Blüher M
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.
-
Boeing H
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany.
-
Boerwinkle E
School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
-
Böger CA
Department of Nephrology, University Hospital Regensburg, Regensburg, 93042, Germany.
-
Bonnycastle LL
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
-
Bork-Jensen J
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
Bots ML
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
-
Bottinger EP
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
-
Bowden DW
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
-
Brandslund I
Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, 7100, Denmark.
-
Breen G
MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London &NIHR Biomedical Research Centre for Mental Health at the Maudsley, London, SE5 8AF, UK.
-
Brilliant MH
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
-
Broer L
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
-
Burt AA
Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
-
Butterworth AS
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Carey DJ
The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.
-
Caulfield MJ
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
-
Chambers JC
Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.
-
Chasman DI
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
-
Chen YI
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
-
Chowdhury R
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Christensen C
Medical Department, Lillebaelt Hospital, Vejle, 7100, Denmark.
-
Chu AY
Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.
-
Cocca M
Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, 34100, Italy.
-
Collins FS
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
-
Cook JP
Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
-
Corley J
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
-
Galbany JC
Department of Human Genetics, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
-
Cox AJ
Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
-
Cuellar-Partida G
Diamantina Institute, University of Qeensland, Brisbane, Queensland, 4072, Australia.
-
Danesh J
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Davies G
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
-
de Bakker PI
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
-
de Borst GJ
Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
-
de Denus S
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
-
de Groot MC
Department of Clinical Chemistry and Haematology, Division of Laboratory and Pharmacy, University Medical Center Utrecht, Utrecht, 3508 GA, The Netherlands.
-
de Mutsert R
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
-
Deary IJ
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
-
Dedoussis G
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.
-
Demerath EW
Division of Epidemiology &Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA.
-
den Hollander AI
Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
-
Dennis JG
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Di Angelantonio E
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Drenos F
Institute of Cardiovascular Science, University College London, London WC1E 6JF, UK.
-
Du M
Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, Washington 98109, USA.
-
Dunning AM
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
-
Easton DF
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Ebeling T
Department of Medicine, Oulu University Hospital, Oulu, 90029, Finland.
-
Edwards TL
Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
-
Ellinor PT
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
-
Elliott P
Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.
-
Evangelou E
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.
-
Farmaki AE
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, 17671, Greece.
-
Faul JD
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan 48104, USA.
-
Feitosa MF
Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, StLouis, Missouri 63108, USA.
-
Feng S
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Ferrannini E
CNR Institute of Clinical Physiology, Pisa, Italy.
-
Ferrario MM
Research Center on Epidemiology and Preventive Medicine, Department of Clinical and Experimental Medicine, University of Insubria, Varese, 21100, Italy.
-
Ferrieres J
Toulouse University School of Medicine, Toulouse, TSA 50032 31059, France.
-
Florez JC
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
-
Ford I
University of Glasgow, Glasgow G12 8QQ, UK.
-
Fornage M
Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
-
Franks PW
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.
-
Frikke-Schmidt R
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
-
Galesloot TE
Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
-
Gan W
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
-
Gandin I
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
-
Gasparini P
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
-
Giedraitis V
Geriatrics, Department of Public Health, Uppsala University, Uppsala, 751 85, Sweden.
-
Giri A
Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
-
Girotto G
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
-
Gordon SD
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
-
Gordon-Larsen P
Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Gorski M
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.
-
Grarup N
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
Grove ML
School of Public Health, Human Genetics Center, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
-
Gudnason V
Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
-
Gustafsson S
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden.
-
Hansen T
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
Harris KM
Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Harris TB
Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, USA.
-
Hattersley AT
University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
-
Hayward C
MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
-
He L
Biodemography of Aging Research Unit, Social Science Research Institute, Duke University, Durham, North Carolina 27708, USA.
-
Heid IM
Department of Genetic Epidemiology, University of Regensburg, Regensburg, D-93051, Germany.
-
Heikkilä K
Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.
-
Helgeland Ø
Department of Pediatrics, Haukeland University Hospital, Bergen, 5021, Norway.
-
Hernesniemi J
Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, 33521, Finland.
-
Hewitt AW
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Victoria, 3002, Australia.
-
Hocking LJ
Generation Scotland, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
-
Hollensted M
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
Holmen OL
K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, 7600, Norway.
-
Hovingh GK
AMC, Department of Vascular Medicine, Amsterdam, 1105 AZ, The Netherlands.
-
Howson JM
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Hoyng CB
Department of Ophthalmology, Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
-
Huang PL
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
-
Hveem K
HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, 7600, Norway.
-
Ikram MA
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
-
Ingelsson E
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, 751 41, Sweden.
-
Jackson AU
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Jansson JH
Department of Public Health &Clinical Medicine, Umeå University, Umeå, SE-90185, Sweden.
-
Jarvik GP
Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
-
Jensen GB
The Copenhagen City Heart Study, Frederiksberg Hospital, Frederiksberg, 2000, Denmark.
-
Jhun MA
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Jia Y
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
-
Jiang X
Department of Preventive Medicine, Keck School of Medicine of the University of California, Los Angeles, California 90089, USA.
-
Johansson S
KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, 5020, Norway.
-
Jørgensen ME
National Institute of Public Health, University of Southern Denmark, Copenhagen, 1353, Denmark.
-
Jørgensen T
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
-
Jousilahti P
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
-
Jukema JW
Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
-
Kahali B
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Kahn RS
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.
-
Kähönen M
Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, 33014, Finland.
-
Kamstrup PR
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
-
Kanoni S
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
-
Kaprio J
Department of Public Health, University of Helsinki, Helsinki, FI-00014, Finland.
-
Karaleftheri M
Echinos Medical Centre, Echinos, Greece.
-
Kardia SL
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Karpe F
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
-
Kee F
UKCRC Centre of Excellence for Public Health Research, Queens University Belfast, Belfast BT12 6BJ, UK.
-
Keeman R
Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands.
-
Kiemeney LA
Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
-
Kitajima H
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
-
Kluivers KB
Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
-
Kocher T
Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald, 17475, Germany.
-
Komulainen P
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
-
Kontto J
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
-
Kooner JS
Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.
-
Kooperberg C
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
-
Kovacs P
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.
-
Kriebel J
German Center for Diabetes Research, München-Neuherberg, 85764, Germany.
-
Kuivaniemi H
The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.
-
Küry S
CHU Nantes, Service de Génétique Médicale, Nantes, 44093, France.
-
Kuusisto J
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
-
La Bianca M
Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
-
Laakso M
Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, 70210, Finland.
-
Lakka TA
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
-
Lange EM
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Lange LA
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Langefeld CD
Department of Biostatistical Sciences and Center for Public Health Genomics, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
-
Langenberg C
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
-
Larson EB
Department of Medicine, University of Washington, Seattle, Washington 98195, USA.
-
Lee IT
Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 407, Taiwan.
-
Lehtimäki T
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.
-
Lewis CE
Division of Preventive Medicine University of Alabama at Birmingham, Birmingham, Alabama 35205, USA.
-
Li H
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
-
Li J
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Palo Alto, California 94304, USA.
-
Li-Gao R
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
-
Lin H
Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
-
Lin LA
Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas 77030, USA.
-
Lin X
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
-
Lind L
Uppsala University, Uppsala, 75185, Sweden.
-
Lindström J
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
-
Linneberg A
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
-
Liu Y
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
-
Liu Y
Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27157, USA.
-
Lophatananon A
Division of Health Sciences, Warwick Medical School, Warwick University, Coventry CV4 7AL, UK.
-
Luan J
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
-
Lubitz SA
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
-
Lyytikäinen LP
Department of Clinical Chemistry, Fimlab Laboratories, Tampere, 33520, Finland.
-
Mackey DA
Centre for Ophthalmology and Vision Science, Lions Eye Institute, University of Western Australia, Perth, Western Australia, 6009, Australia.
-
Madden PA
Department of Psychiatry, Washington University, Saint Louis, Missouri 63110, USA.
-
Manning AK
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
-
Männistö S
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
-
Marenne G
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
-
Marten J
MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
-
Martin NG
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
-
Mazul AL
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Meidtner K
German Center for Diabetes Research, München-Neuherberg, 85764, Germany.
-
Metspalu A
Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
-
Mitchell P
Westmead Millennium Institute of Medical Research, Centre for Vision Research and Department of Ophthalmology, University of Sydney, Sydney, New South Wales, 2022, Australia.
-
Mohlke KL
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Mook-Kanamori DO
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2300 RC, The Netherlands.
-
Morgan A
Department of Medical Sciences, University of Trieste, Trieste, 34137, Italy.
-
Morris AD
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
-
Morris AP
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
-
Müller-Nurasyid M
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, D-85764, Germany.
-
Munroe PB
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
-
Nalls MA
Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA.
-
Nauck M
DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
-
Nelson CP
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
-
Neville M
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
-
Nielsen SF
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
-
Nikus K
Department of Cardiology, Heart Center, Tampere University Hospital and School of Medicine, University of Tampere, Tampere, 33521, Finland.
-
Njølstad PR
Department of Pediatrics, Haukeland University Hospital, Bergen, 5021, Norway.
-
Nordestgaard BG
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
-
Ntalla I
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
-
O'Connel JR
Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
-
Oksa H
Department of Medicine, Tampere University Hospital, Tampere, 33521, Finland.
-
Loohuis LM
Center for Neurobehavioral Genetics, UCLA, Los Angeles, California 90095, USA.
-
Ophoff RA
Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands.
-
Owen KR
Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK.
-
Packard CJ
University of Glasgow, Glasgow G12 8QQ, UK.
-
Padmanabhan S
University of Glasgow, Glasgow G12 8QQ, UK.
-
Palmer CN
Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Medical Research Institute, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK.
-
Pasterkamp G
Laboratory of Clinical Chemistry and Hematology, Division Laboratories and Pharmacy, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
-
Patel AP
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
-
Pattie A
Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
-
Pedersen O
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
Peissig PL
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
-
Peloso GM
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
-
Pennell CE
School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia.
-
Perola M
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
-
Perry JA
Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
-
Perry JR
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
-
Person TN
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA.
-
Pirie A
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
-
Polasek O
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
-
Posthuma D
Center for Neurogenomics and Cognitive Research, Department Complex Trait Genetics, VU University, Amsterdam, 1081 HV, The Netherlands.
-
Raitakari OT
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, 20521, Finland.
-
Rasheed A
Centre for Non-Communicable Diseases, Karachi, Pakistan.
-
Rauramaa R
Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
-
Reilly DF
MRL, Merck &Co., Inc., Genetics and Pharmacogenomics, Boston, Massachusetts 02115, USA.
-
Reiner AP
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
-
Renström F
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.
-
Ridker PM
Division of Preventive Medicine, Brigham and Women's and Harvard Medical School, Boston, Massachusetts 02215, USA.
-
Rioux JD
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
-
Robertson N
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
-
Robino A
Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
-
Rolandsson O
Department of Public Health &Clinical Medicine, Umeå University, Umeå, SE-90185, Sweden.
-
Rudan I
Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
-
Ruth KS
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
-
Saleheen D
Centre for Non-Communicable Diseases, Karachi, Pakistan.
-
Salomaa V
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
-
Samani NJ
Department of Cardiovascular Sciences, Univeristy of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK.
-
Sandow K
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
-
Sapkota Y
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, 4006, Australia.
-
Sattar N
University of Glasgow, Glasgow G12 8QQ, UK.
-
Schmidt MK
Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, 1066 CX, The Netherlands.
-
Schreiner PJ
Division of Epidemiology &Community Health University of Minnesota, Minneapolis, Minnesota 55454, USA.
-
Schulze MB
German Center for Diabetes Research, München-Neuherberg, 85764, Germany.
-
Scott RA
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
-
Segura-Lepe MP
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK.
-
Shah S
Duke University, Durham, North Carolina 27703, USA.
-
Sim X
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Sivapalaratnam S
Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
-
Small KS
Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK.
-
Smith AV
Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland.
-
Smith JA
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Southam L
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
-
Spector TD
Department of Twin Research and Genetic Epidemiology, Kingís College London, London SE1 7EH, UK.
-
Speliotes EK
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Starr JM
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
-
Steinthorsdottir V
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.
-
Stringham HM
Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Stumvoll M
IFB Adiposity Diseases, University of Leipzig, Leipzig, 04103, Germany.
-
Surendran P
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
't Hart LM
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands.
-
Tansey KE
College of Biomedical and Life Sciences, Cardiff University, Cardiff, CF14 4EP, UK.
-
Tardif JC
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
-
Taylor KD
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
-
Teumer A
Institute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
-
Thompson DJ
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Thorsteinsdottir U
deCODE Genetics/Amgen inc., Reykjavik, 101, Iceland.
-
Thuesen BH
Research Center for Prevention and Health, Capital Region of Denmark, Glostrup, DK-2600, Denmark.
-
Tönjes A
Center for Pediatric Research, Department for Women's and Child Health, University of Leipzig, Leipzig, 04103, Germany.
-
Tromp G
The Sigfried and Janet Weis Center for Research, Danville, Pennsylvania 17822, USA.
-
Trompet S
Department of Cardiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
-
Tsafantakis E
Anogia Medical Centre, Anogia, Greece.
-
Tuomilehto J
National Institute for Health and Welfare, Helsinki, FI-00271, Finland.
-
Tybjaerg-Hansen A
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
-
Tyrer JP
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
-
Uher R
Department of Psychiatry, Dalhousie University, Halifax B3H 4R2, Canada.
-
Uitterlinden AG
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
-
Ulivi S
Institute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, 34137, Italy.
-
van der Laan SW
Laboratory of Experimental Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherlands.
-
Van Der Leij AR
University of Amsterdam, Department of Brain &Cognition, Amsterdam, 1018 WS, The Netherlands.
-
van Duijn CM
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
-
van Schoor NM
Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, 1007MB, The Netherlands.
-
van Setten J
Department of Cardiology, Division Heart &Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
-
Varbo A
Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
-
Varga TV
Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Malmö, SE-20502, Sweden.
-
Varma R
USC Roski Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California 90089, USA.
-
Edwards DR
Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee 37203, USA.
-
Vermeulen SH
Radboud University Medical Center, Nijmegen, 6500 HB, The Netherlands.
-
Vestergaard H
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
Vitart V
MRCHGU, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
-
Vogt TF
MRL, Merck &Co., Inc., Cardiometabolic Disease, Kenilworth, New Jersey 07033, USA.
-
Vozzi D
Division of Experimental Genetics, Sidra Medical and Research Center, Doha, 26999, Qatar.
-
Walker M
Institute of Cellular Medicine, The Medical School, Newcastle University, Newcastle NE2 4HH, UK.
-
Wang F
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
-
Wang CA
School of Women's and Infants' Health, The University of Western Australia, Perth, Western Australia, 6009, Australia.
-
Wang S
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
-
Wang Y
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
-
Wareham NJ
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
-
Warren HR
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
-
Wessel J
Departments of Epidemiology &Medicine, Diabetes Translational Research Center, Fairbanks School of Public Health &School of Medicine, Indiana University, Indiana 46202, USA.
-
Willems SM
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
-
Wilson JG
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
-
Witte DR
Danish Diabetes Academy, Odense, 5000, Denmark.
-
Woods MO
Memorial University, Faculty of Medicine, Discipline of Genetics, St. John's, Newfoundland A1B 3V6, Canada.
-
Wu Y
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27514, USA.
-
Yaghootkar H
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
-
Yao J
Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Torrance, California 90502, USA.
-
Yao P
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
-
Yerges-Armstrong LM
Program in Personalized Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
-
Young R
MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
-
Zeggini E
Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
-
Zhan X
Department of Clinical Sciences, Quantitative Biomedical Research Center, Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
-
Zhang W
Department of Cardiology, London North West Healthcare NHS Trust, Ealing Hospital, Middlesex UB1 3HW, UK.
-
Zhao JH
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
-
Zhao W
Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
-
Zhao W
Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Zheng H
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of the Chinese Academy of Sciences, Shanghai, People's Republic of China, Shanghai, 200031, China.
-
Zhou W
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.
-
Rotter JI
Department of Epidemiology and Carolina Center of Genome Sciences, Chapel Hill, North Carolina 27514, USA.
-
Boehnke M
NHLBI Framingham Heart Study, Framingham, Massachusetts 01702, USA.
-
Kathiresan S
The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
-
McCarthy MI
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
-
Willer CJ
Department of Molecular Biology and Genetics, Aarhus University, Aarhus, 8000, Denmark.
-
Stefansson K
Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, 1010, Switzerland.
-
Borecki IB
Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015 GE, The Netherlands.
-
Liu DJ
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
-
North KE
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK.
-
Heard-Costa NL
Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA.
-
Pers TH
William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
-
Lindgren CM
Montreal Heart Institute, Montreal, Quebec H1T 1C8, Canada.
-
Oxvig C
-
Kutalik Z
-
Rivadeneira F
-
Loos RJ
-
Frayling TM
-
Hirschhorn JN
-
Deloukas P
-
Lettre G
Show more…
English
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding variants with lower minor-allele frequencies (in the range of 0.1-4.8%) and effects of up to 2 centimetres per allele (such as those in IHH, STC2, AR and CRISPLD2), greater than ten times the average effect of common variants. In functional follow-up studies, rare height-increasing alleles of STC2 (giving an increase of 1-2 centimetres per allele) compromised proteolytic inhibition of PAPP-A and increased cleavage of IGFBP-4 in vitro, resulting in higher bioavailability of insulin-like growth factors. These 83 height-associated variants overlap genes that are mutated in monogenic growth disorders and highlight new biological candidates (such as ADAMTS3, IL11RA and NOX4) and pathways (such as proteoglycan and glycosaminoglycan synthesis) involved in growth. Our results demonstrate that sufficiently large sample sizes can uncover rare and low-frequency variants of moderate-to-large effect associated with polygenic human phenotypes, and that these variants implicate relevant genes and pathways.
-
Language
-
-
Open access status
-
green
-
Identifiers
-
-
Persistent URL
-
https://sonar.ch/global/documents/76893
Statistics
Document views: 26
File downloads: