New developments in RiPP discovery, enzymology and engineering.
Journal article

New developments in RiPP discovery, enzymology and engineering.

  • Montalbán-López M Department of Microbiology, University of Granada, Spain.
  • Scott TA Institute of Microbiology, ETH Zürich, Zürich, Switzerland. jpiel@ethz.ch.
  • Ramesh S Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. vddonk@illinois.edu.
  • Rahman IR Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • van Heel AJ Dept. of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands. o.p.kuipers@rug.nl.
  • Viel JH Dept. of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands. o.p.kuipers@rug.nl.
  • Bandarian V Department of Chemistry, University of Utah, Salt Lake City, UT, USA.
  • Dittmann E Institute of Biochemistry and Biology, University of Potsdam, Germany.
  • Genilloud O Fundación MEDINA, Granada, Spain.
  • Goto Y Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo, Japan.
  • Grande Burgos MJ Department of Microbiology, University of Jaén, Spain.
  • Hill C APC Microbiome Ireland, School of Microbiology, University College Cork, Cork, Ireland.
  • Kim S Department of Chemistry, Seoul National University, South Korea.
  • Koehnke J School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.
  • Latham JA Department of Chemistry and Biochemistry, University of Denver, Denver, CO, USA.
  • Link AJ Departments of Chemical and Biological Engineering, Chemistry, and Molecular Biology, Princeton University, Princeton, NJ, USA.
  • Martínez B Dept. of Technology and Biotechnology of Dairy Products, Dairy Research Institute-IPLA, Consejo Superior de Investigaciones Científicas-CSIC, Villaviciosa, Spain.
  • Nair SK Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. vddonk@illinois.edu and Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA and Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
  • Nicolet Y Université Grenoble-Alpes, CEA, CNRS, IBS, Metalloproteins Unit, Grenoble, France.
  • Rebuffat S Laboratory Molecules of Communication and Adaptation of Microorganisms-MCAM (UMR 7245 CNRS-MNHN), National Museum of Natural History, Paris, France.
  • Sahl HG Department of Pharmaceutical Microbiology, University of Bonn, Bonn, Germany.
  • Sareen D Department of Biochemistry, Panjab University, Chandigarh-160014, India.
  • Schmidt EW Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, USA.
  • Schmitt L Institute of Biochemistry, Heinrich Heine University Düsseldorf, Duesseldorf, Germany.
  • Severinov K Waksman Institute, Rutgers University, Piscataway NJ and Skolkovo Institute of Science and Technology, Skolkovo, Russia.
  • Süssmuth RD Department of Chemistry, Technische Universität Berlin, Berlin, Germany.
  • Truman AW Department of Microbiology, University of Granada, Spain and.
  • Wang H Department of Microbiology, University of Granada, Spain and.
  • Weng JK Department of Microbiology, University of Granada, Spain and.
  • van Wezel GP Department of Microbiology, University of Granada, Spain and.
  • Zhang Q Department of Microbiology, University of Granada, Spain and.
  • Zhong J Department of Microbiology, University of Granada, Spain and.
  • Piel J Institute of Microbiology, ETH Zürich, Zürich, Switzerland. jpiel@ethz.ch.
  • Mitchell DA Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. douglasm@illinois.edu and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. vddonk@illinois.edu and Department of Microbiology, University of Granada, Spain and.
  • Kuipers OP Dept. of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, The Netherlands. o.p.kuipers@rug.nl.
  • van der Donk WA Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA. vddonk@illinois.edu and Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL, USA and Department of Microbiology, University of Granada, Spain and and.
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  • 2020-09-16
Published in:
  • Natural product reports. - 2020
English Covering: up to June 2020Ribosomally-synthesized and post-translationally modified peptides (RiPPs) are a large group of natural products. A community-driven review in 2013 described the emerging commonalities in the biosynthesis of RiPPs and the opportunities they offered for bioengineering and genome mining. Since then, the field has seen tremendous advances in understanding of the mechanisms by which nature assembles these compounds, in engineering their biosynthetic machinery for a wide range of applications, and in the discovery of entirely new RiPP families using bioinformatic tools developed specifically for this compound class. The First International Conference on RiPPs was held in 2019, and the meeting participants assembled the current review describing new developments since 2013. The review discusses the new classes of RiPPs that have been discovered, the advances in our understanding of the installation of both primary and secondary post-translational modifications, and the mechanisms by which the enzymes recognize the leader peptides in their substrates. In addition, genome mining tools used for RiPP discovery are discussed as well as various strategies for RiPP engineering. An outlook section presents directions for future research.
Language
  • English
Open access status
closed
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Persistent URL
https://sonar.ch/global/documents/77346
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