Shedding of APP limits its synaptogenic activity and cell adhesion properties.

• Stahl R Center of Molecular Biology ZMBH, University of Heidelberg Heidelberg, Germany ; Department of Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich Munich, Germany.
• Schilling S Department of Human Biology and Human Genetics, Technical University of Kaiserslautern Kaiserslautern, Germany.
• Soba P Center of Molecular Biology ZMBH, University of Heidelberg Heidelberg, Germany ; Center for Molecular Neurobiology (ZMNH), University of Hamburg Hamburg, Germany.
• Rupp C Department of Human Biology and Human Genetics, Technical University of Kaiserslautern Kaiserslautern, Germany.
• Hartmann T Deutsches Institut für DemenzPrävention, Experimental Neurology, Saarland University Homburg/Saar, Germany.
• Wagner K Center of Molecular Biology ZMBH, University of Heidelberg Heidelberg, Germany ; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern Kaiserslautern, Germany.
• Merdes G Center of Molecular Biology ZMBH, University of Heidelberg Heidelberg, Germany ; Department of Biosystems Science and Engineering, ETH Zürich Basel, Switzerland.
• Eggert S Department of Human Biology and Human Genetics, Technical University of Kaiserslautern Kaiserslautern, Germany.
• Kins S Center of Molecular Biology ZMBH, University of Heidelberg Heidelberg, Germany ; Department of Human Biology and Human Genetics, Technical University of Kaiserslautern Kaiserslautern, Germany ; Deutsches Institut für DemenzPrävention, Experimental Neurology, Saarland University Homburg/Saar, Germany.

APP processing

Alzheimer’s disease

SAM

amyloid precursor protein

cell adhesion

synaptogenic activity