Altered Connectivity Between Cerebellum, Visual, and Sensory-Motor Networks in Autism Spectrum Disorder: Results from the EU-AIMS Longitudinal European Autism Project.
- Oldehinkel M Brain and Mental Health Laboratory, Monash Institute of Cognitive and Clinical Neurosciences and School of Psychological Sciences, Monash University, Victoria, Australia; Department of Cognitive Neuroscience, Radboud University Medical Center, the Netherlands; Donders Institute for Brain, Cognition, and Behavior, Radboud University, the Netherlands. Electronic address: marianne.oldehinkel@monash.edu.
- Mennes M Donders Institute for Brain, Cognition, and Behavior, Radboud University, the Netherlands.
- Marquand A Department of Cognitive Neuroscience, Radboud University Medical Center, the Netherlands; Donders Institute for Brain, Cognition, and Behavior, Radboud University, the Netherlands; Department of Neuroimaging, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
- Charman T Department of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
- Tillmann J Department of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
- Ecker C Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Frankfurt am Main, Goethe University, Frankfurt, Germany.
- Dell'Acqua F Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
- Brandeis D Child and Adolescent Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, Zurich, Switzerland; Center for Integrative Human Physiology Zurich, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
- Banaschewski T Child and Adolescent Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
- Baumeister S Child and Adolescent Psychiatry, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
- Moessnang C Center for Applied Neuroscience, Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
- Baron-Cohen S Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom.
- Holt R Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom.
- Bölte S Center of Neurodevelopmental Disorders, Division of Neuropsychiatry, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Child and Adolescent Psychiatry, Center for Psychiatry Research, Stockholm County Council, Stockholm, Sweden.
- Durston S Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands.
- Kundu P Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, New York.
- Lombardo MV Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom; Department of Psychology, Center for Applied Neuroscience, University of Cyprus, Nicosia, Cyprus.
- Spooren W Roche Pharmaceutical Research and Early Development, NORD Discovery and Translational Area, Roche Innovation Center Basel, Basel, Switzerland.
- Loth E Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
- Murphy DGM Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, United Kingdom.
- Beckmann CF Department of Cognitive Neuroscience, Radboud University Medical Center, the Netherlands; Donders Institute for Brain, Cognition, and Behavior, Radboud University, the Netherlands; Centre for Functional MRI of the Brain, University of Oxford, Oxford, United Kingdom.
- Buitelaar JK Department of Cognitive Neuroscience, Radboud University Medical Center, the Netherlands; Donders Institute for Brain, Cognition, and Behavior, Radboud University, the Netherlands; Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, the Netherlands.
- 2019-02-04
Published in:
- Biological psychiatry. Cognitive neuroscience and neuroimaging. - 2019
Autism
Cerebellum
Functional connectivity
Resting-state fMRI
Sensory networks
Visual-motor integration
Adolescent
Adult
Autism Spectrum Disorder
Brain Mapping
Case-Control Studies
Cerebellum
Child
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Neural Pathways
Sensorimotor Cortex
Visual Cortex
Young Adult
English
BACKGROUND
Resting-state functional magnetic resonance imaging-based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered by small samples and a focus on a limited number of networks, with networks underlying sensory processing being largely underexamined. We aimed to comprehensively characterize ASD-related alterations within and between 20 well-characterized resting-state networks using baseline data from the EU-AIMS (European Autism Interventions-A Multicentre Study for Developing New Medications) Longitudinal European Autism Project.
METHODS
Resting-state functional magnetic resonance imaging data was available for 265 individuals with ASD (7.5-30.3 years; 73.2% male) and 218 typically developing individuals (6.9-29.8 years; 64.2% male), all with IQ > 70. We compared functional connectivity within 20 networks-obtained using independent component analysis-between the ASD and typically developing groups, and related functional connectivity within these networks to continuous (overall) autism trait severity scores derived from the Social Responsiveness Scale Second Edition across all participants. Furthermore, we investigated case-control differences and autism trait-related alterations in between-network connectivity.
RESULTS
Higher autism traits were associated with increased connectivity within salience, medial motor, and orbitofrontal networks. However, we did not replicate previously reported case-control differences within these networks. The between-network analysis did reveal case-control differences showing on average 1) decreased connectivity of the visual association network with somatosensory, medial, and lateral motor networks, and 2) increased connectivity of the cerebellum with these sensory and motor networks in ASD compared with typically developing subjects.
CONCLUSIONS
We demonstrate ASD-related alterations in within- and between-network connectivity. The between-network alterations broadly affect connectivity between cerebellum, visual, and sensory-motor networks, potentially underlying impairments in multisensory and visual-motor integration frequently observed in ASD.
Resting-state functional magnetic resonance imaging-based studies on functional connectivity in autism spectrum disorder (ASD) have generated inconsistent results. Interpretation of findings is further hampered by small samples and a focus on a limited number of networks, with networks underlying sensory processing being largely underexamined. We aimed to comprehensively characterize ASD-related alterations within and between 20 well-characterized resting-state networks using baseline data from the EU-AIMS (European Autism Interventions-A Multicentre Study for Developing New Medications) Longitudinal European Autism Project.
METHODS
Resting-state functional magnetic resonance imaging data was available for 265 individuals with ASD (7.5-30.3 years; 73.2% male) and 218 typically developing individuals (6.9-29.8 years; 64.2% male), all with IQ > 70. We compared functional connectivity within 20 networks-obtained using independent component analysis-between the ASD and typically developing groups, and related functional connectivity within these networks to continuous (overall) autism trait severity scores derived from the Social Responsiveness Scale Second Edition across all participants. Furthermore, we investigated case-control differences and autism trait-related alterations in between-network connectivity.
RESULTS
Higher autism traits were associated with increased connectivity within salience, medial motor, and orbitofrontal networks. However, we did not replicate previously reported case-control differences within these networks. The between-network analysis did reveal case-control differences showing on average 1) decreased connectivity of the visual association network with somatosensory, medial, and lateral motor networks, and 2) increased connectivity of the cerebellum with these sensory and motor networks in ASD compared with typically developing subjects.
CONCLUSIONS
We demonstrate ASD-related alterations in within- and between-network connectivity. The between-network alterations broadly affect connectivity between cerebellum, visual, and sensory-motor networks, potentially underlying impairments in multisensory and visual-motor integration frequently observed in ASD.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.bpsc.2018.11.010
- PMID 30711508
- Persistent URL
- https://sonar.ch/global/documents/77656
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