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Planar microcoil-based microfluidic NMR probes.
Journal article

Planar microcoil-based microfluidic NMR probes.

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  • 2003-09-27
Published in:
  • Journal of magnetic resonance (San Diego, Calif. : 1997). - 2003
Electronics
Equipment Design
Equipment Failure Analysis
Magnetic Resonance Spectroscopy
Microchemistry
Microfluidics
Miniaturization
Sensitivity and Specificity
Sucrose
Transducers
English Microfabricated small-volume NMR probes consisting of electroplated planar microcoils integrated on a glass substrate with etched microfluidic channels are fabricated and tested. 1H NMR spectra are acquired at 300 MHz with three different probes having observed sample volumes of respectively 30, 120, and 470 nL. The achieved sensitivity enables acquisition of an 1H spectrum of 160 microg sucrose in D2O, corresponding to a proof-of-concept for on-chip NMR spectroscopy. Increase of mass-sensitivity with coil diameter reduction is demonstrated experimentally for planar microcoils. Models that enable quantitative prediction of the signal-to-noise ratio and of the influence of microfluidic channel geometry on spectral resolution are presented and successfully compared to the experimental data. The main factor presently limiting sensitivity for high-resolution applications is identified as being probe-induced static magnetic field distortions. Finally, based on the presented model and measured data, future performance of planar microcoil-based microfluidic NMR probes is extrapolated and discussed.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/77971
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