Journal article
Interferences in the measurement of circulating phosphate: a literature review.
- Molinaris V Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.
- Bianchetti MG Università della Svizzera Italiana, Lugano, Switzerland.
- Milani GP Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.
- Lava SAG Pediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois (CHUV), and University of Lausanne, 1010 Lausanne, Switzerland.
- Bruna RD EOLAB, Department of Laboratory medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
- Simonetti GD Pediatric Institute of Southern Switzerland, Ospedale San Giovanni, Bellinzona, Switzerland.
- Faré PB Department of Internal Medicine, Ente Ospedaliero Cantonale, Locarno, Switzerland.
- 2020-06-19
Published in:
- Clinical chemistry and laboratory medicine. - 2020
English
Background Inorganic phosphate in blood is currently determined by the reaction with molybdate. This report aims at reviewing conditions underlying spuriously altered levels of circulating inorganic phosphate. Content A systematic search of the Excerpta Medica, the National Library Database and the Web of Science database was conducted without language restriction from the earliest publication date available through January 31, 2020. Summary For the analysis, 80 reports published in English (n = 77), French (n = 1), German (n = 1) and Spanish (n = 1) were retained. Well-documented pseudohyperphosphatemia was observed in individuals exposed to liposomal amphotericin, in patients affected by a gammopathy, in patients with hyperlipidemia and in patients with hyperbilirubinemia. An unexplained elevated inorganic phosphate level sometimes provided a clue to the diagnosis of a gammopathy. Well-documented cases of pseudohypophosphatemia were observed in patients on large amounts of intravenous mannitol. Finally, pseudohypophosphatemia was occasionally observed on treatment with liposomal amphotericin and in patients with a gammopathy. Outlook In order to avoid unnecessary testing and treatment, the phenomenon of spuriously altered inorganic phosphate should be recognized. An unexplained hyperphosphatemia may provide a clue to the diagnosis of a gammopathy or a severe hyperlipidemia.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1515/cclm-2020-0281
- PMID 32549132
- Persistent URL
- https://sonar.ch/global/documents/78028
Statistics
Document views: 28
File downloads: