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Depression, Migraine With Aura and Migraine Without Aura: Their Familiality and Interrelatedness
Journal article

Depression, Migraine With Aura and Migraine Without Aura: Their Familiality and Interrelatedness

  • Ball, HA Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London
  • Samaan, Z Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London
  • Brewster, S GlaxoSmithKline, Research and Development, Greenford
  • Craddock, N Department of Psychiatry, University of Birmingham, Birmingham, UK
  • Gill, M Department of Psychiatry, Trinity Centre for Health Sciences, Dublin, Ireland
  • Korszun, A Barts and The London, Queen Mary's School of Medicine and Dentistry
  • Maier, W Department of Psychiatry, University of Bonn, Bonn
  • Middleton, L Division of Neurosciences and Mental Health, Imperial College, London
  • Mors, O Centre for Psychiatric Research, University of Aarhus, Aarhus, Denmark
  • Owen, MJ Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff
  • Perry, J GlaxoSmithKline, Research and Development, Greenford
  • Preisig, M Department of Adult Psychiatry, University Hospital of Lausanne, Prilly-Lausanne, Switzerland
  • Rice, J Department of Psychiatry, Washington University, St Louis, MO, USA
  • Rietschel, M Central Institute of Mental Health, Mannheim, Germany
  • Jones, L Department of Psychiatry, University of Birmingham, Birmingham, UK
  • Jones, I Department of Psychological Medicine, School of Medicine, Cardiff University, Cardiff
  • Farmer, AE Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London
  • McGuffin, P Medical Research Council Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London
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  • 2009-8-1
Published in:
  • Cephalalgia. - SAGE Publications. - 2009, vol. 29, no. 8, p. 848-854
Clinical Neurology
General Medicine
English Migraine is frequently comorbid with depression. There appear to be common aetiological factors for both disorders, but the aetiology of migraine within depressed patients, in particular the significance of aura, has been little studied. A large sample of concordantly depressed sibling pairs [the Depression-Network (DeNT) sample] was assessed as having migraine with aura (MA), migraine without aura (MoA), probable migraine or no migraine according to International Headache Society guidelines. Correlations between siblings' migraine status were used to assess the nature of familial liability to migraine. A multiple threshold isocorrelational model fit best, in which different syndromes are conceptualized as different severities of one underlying dimension rather than as having separate aetiologies. Thus, MA and MoA were found to be different forms of the same disorder, with MA occupying the more extreme end of the spectrum of liability. Implications for our understanding of the relationship between migraine and depression are discussed.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/78058
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