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Journal article

Ubiquitylation of ion channels.

  • Abriel H Department of Pharmacology and Toxicology, University of Lausanne, Switzerland. Hugues.Abriel@unil.ch
  • Staub O
  • 2005-11-17
Published in:
  • Physiology (Bethesda, Md.). - 2005
Amino Acid Motifs
Animals
Endoplasmic Reticulum
Humans
Ion Channels
Mutation
Protein Folding
Ubiquitin
English Ubiquitylation (i.e., covalent attachment of ubiquitin moieties to proteins) of ion channels allows regulation of their activity and fate. Nedd4/Nedd4-like ubiquitin-protein ligases bind to, ubiquitylate, and modulate the internalization of several channels bearing PY motifs, whereas endoplasmic reticulum-associated degradation (involving ubiquitylation) plays an important role in the biogenesis of normal and defective channels.
Language
  • English
Open access status
green
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Persistent URL
https://sonar.ch/global/documents/78329
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