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Journal article

Mechanisms of inflammation in gout.

  • Busso N Service de Rheumatologie, Centre Hospitalier Universitaire Vaudois, Université de Lausanne, Avenue Pierre Decker, 1011 Lausanne, Suisse.
  • So A
  • 2010-05-06
Published in:
  • Arthritis research & therapy. - 2010
Acute Disease
Animals
Carrier Proteins
Chemotaxis, Leukocyte
Crystallization
Disease Models, Animal
Gout
Humans
Inflammation
Interleukin-1beta
Leukocytes
NLR Family, Pyrin Domain-Containing 3 Protein
Phagocytosis
Uric Acid
English An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1beta release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.
Language
  • English
Open access status
gold
Identifiers
Persistent URL
https://sonar.ch/global/documents/78376
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