Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex.
- Messori L Dipartimento di Chimica, Ugo Schiff, Università di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
- Casini A Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.
- Gabbiani C Dipartimento di Chimica, Ugo Schiff, Università di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy.
- Michelucci E Mass Spectrometry Centre (CISM), Università di Firenze, Via U. Schiff 6, 50019 Sesto Fiorentino, Italy.
- Cubo L Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 7, 28049 Madrid, Spain.
- Ríos-Luci C Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
- Padrón JM Instituto Universitario de Bio-Orgánica "Antonio González" (IUBO-AG), Universidad de La Laguna, C/Astrofísico Francisco Sánchez 2, 38206 La Laguna, Spain.
- Navarro-Ranninger C Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 7, 28049 Madrid, Spain.
- Quiroga AG Universidad Autónoma de Madrid, C/Francisco Tomás y Valiente, 7, 28049 Madrid, Spain.
- 2014-06-06
Published in:
- ACS medicinal chemistry letters. - 2010
English
Novel and surprising biological properties were disclosed for the platinum(II) complex cis-diiodidodiisopropylamineplatinum(II). Remarkably, this new platinum(II) complex manifests pronounced antiproliferative properties in vitro, in some cases superior to those of cisplatin. A peculiar reactivity with the model protein cytochrome c was indeed highlighted based on the loss of amine ligands and retention of iodides.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1021/ml100081e
- PMID 24900222
- Persistent URL
- https://sonar.ch/global/documents/80253
Statistics
Document views: 35
File downloads:
- Full-text: 0