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The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro.
Journal article

The central region of human immunodeficiency virus type 1 p6 protein (Gag residues S14-I31) is dispensable for the virus in vitro.

  • Bleiber G Division of Infectious Diseases, University of Lausanne, Lausanne, Switzerland.
  • Peters S Division of Infectious Diseases, University of Lausanne, Lausanne, Switzerland.
  • Martinez R Division of Infectious Diseases, University of Lausanne, Lausanne, Switzerland.
  • Cmarko D University Hospital, and Center of Electron Microscopy, University of Lausanne, Lausanne, Switzerland.
  • Meylan P Institute of Microbiology, University of Lausanne, Lausanne, Switzerland.
  • Telenti A Institute of Microbiology, University of Lausanne, Lausanne, Switzerland.
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  • 2004-03-25
Published in:
  • The Journal of general virology. - 2004
Amino Acid Sequence
Gene Products, gag
Gene Products, pol
HIV Infections
HIV-1
Humans
In Vitro Techniques
Molecular Sequence Data
Phenotype
Polymorphism, Genetic
Recombination, Genetic
Sequence Deletion
Virulence
Virus Replication
English The human immunodeficiency virus type 1 p6 region encodes p6(Gag) and the transframe p6(Pol) protein. The Gag frame encodes an N-terminal late assembly L domain and a C-terminal Vpr binding domain. In the Pol frame, substitution at a C-terminal motif decreases protease autocleavage. The role of the highly polymorphic central region of p6, comprising amino acids S14-I31 (p6(Gag)) and R20-D39 (p6(Pol)), is unclear. Analysis of this central region demonstrated that 35 % of p6(Gag) appears to be dispensable for virus propagation in vitro and smaller deletion and insertion polymorphisms can be tolerated in vivo. Extensive Pol deletion (deltaR20-D39, 42 % of p6(Pol)) did not alter protease autocleavage.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://sonar.ch/global/documents/8092
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