Back
Hematological support in patients undergoing allogenetic bone marrow transplantation.
Journal article

Hematological support in patients undergoing allogenetic bone marrow transplantation.

  • 1988-01-01
Published in:
  • Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. - 1988
Adolescent
Adult
Anemia, Aplastic
Blood Transfusion
Bone Marrow Transplantation
Child
Child, Preschool
Erythrocyte Transfusion
Female
Humans
Immune Sera
Immunoglobulins
Immunoglobulins, Intravenous
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Acute
Male
Middle Aged
Platelet Transfusion
Precursor Cell Lymphoblastic Leukemia-Lymphoma
English Bone marrow transplantation is impossible without effective support with blood components during the period of pancytopenia before graft function appears. We analyzed 39 patients with leukemia and three patients with severe aplastic anemia with regard to the pre- and postgrafting requirements for RBC and PLT transfusions. Overall a median of eight RBC and four PLT concentrates were necessary in all 42 patients after allogeneic BMT (ranges, 1-32 RBC and 1-11 PLT units). Requirements were identical irrespective of the underlying disease (ALL, AML, CML, SAA). Transfusion need for RBC and PLT concentrates increased in patients over 30 years old and with a major red blood group AB0 barrier between marrow donor and recipient. The presence of grade II-IV GvHD increased RBC requirements significantly, but not PLT requirements. In addition these patients were dependent on RBC transfusions for significantly longer periods. Only one patient required therapeutic granulocyte transfusions. In a CMV-negative patient with a CMV-negative marrow donor, who died of veno-occlusive disease, cytomegalovirus was transmitted inadvertently by a seropositive PLT concentrate in his final course. Our transfusion strategy included frozen deglycerolized RBC concentrates and single donor PLT concentrates, collected mainly from the marrow donor by a cell separator. All blood products were irradiated in vitro with 1500 cGy before transfusion. An optimal transfusion policy starting before BMT can contribute to successful bone marrow transplantation.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/812
Statistics
Document views: 16 File downloads: